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Published on: November 20, 2018
Poly-ε-caprolactone tungsten oxide nanoparticles as a contrast agent for X-ray computed tomography
Anshuman Jakhmola1, Nicolas Anton1, Halina Anton2
1University of Strasbourg, Faculty of Pharmacy, 74 Route du Rhin, 67401 Illkirch, France; CNRS 7199, Laboratoire de Conception et Application de Molécules Bioactives, équipe de Pharmacie Biogalénique, 67401 Illkirch, France.
Abstract:
Inorganic nanomaterials based on heavy elements represent a new class of contrast agents for X-ray computed tomography (CT). Recent advances have shown that these materials are highly suited for CT imaging due to their high density and X-ray absorption capabilities. In this contribution, we demonstrated that tungsten oxide (WO3) nanoparticles coated by poly-ε-caprolactone (PCL) can be used as efficient contrast agent for CT imaging. The obtained particles were characterized by electron microscopy (TEM and SEM), and dynamic light scattering (DLS). We also validated their use for enhanced in vivo imaging, since these nanoparticles were observed to display high X-ray attenuation properties and circulation time (up to 3 h), permitting blood pool imaging.
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