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Tumor Protein p63/microRNA Network in Epithelial Cancer Cells

Edward A Ratovitski1

  • 1Department of Otolaryngology/Head and Neck Surgery, Head and Neck Cancer Research Division, The Johns Hopkins University School of Medicine, Cancer Research Building II, 1550 Orleans Street, Baltimore, MD 21231, U.S.A.

Current Genomics
|January 8, 2014
PubMed

Insights

Tumor protein 63 (TP63) and microRNAs regulate cancer cell stress responses, impacting chemotherapy effectiveness and chemoresistance in epithelial cancers. This network influences key cellular processes, offering new therapeutic strategies.

Area of Science:

  • Molecular Biology
  • Cancer Research
  • Epigenetics

Background:

  • Non-coding microRNAs regulate cancer cell responses to stress, including apoptosis, cell cycle arrest, and autophagy.
  • Multiple molecular layers, such as epigenetic regulation and RNA processing, are involved in these cellular responses.
  • The interplay between tumor protein (TP)-p53 family members and microRNAs is crucial for cancer cell response to chemotherapy and chemoresistance.

Purpose of the Study:

  • To investigate the role of TP63 in modulating microRNA expression.
  • To elucidate the TP63/microRNA network's involvement in epithelial cancer biology and chemoresistance.
  • To explore potential novel chemotherapeutic strategies based on this network.

Main Methods:

  • Analysis of TP63-modulated microRNAs in various epithelial cancers.
  • Investigation of the TP63/microRNA network's impact on cellular processes like proliferation, differentiation, and metabolism.
  • Examination of the network's role in chemoresistance mechanisms.

Main Results:

  • TP63 modulates numerous microRNAs involved in epithelial cell regulation (proliferation, differentiation, senescence, stemness, EMT).
  • The TP63/microRNA network is implicated in epithelial cancers, including squamous cell carcinoma, ovarian, prostate, gastric, bladder, and breast tumors.
  • This network significantly influences cancer cell chemoresistance.

Conclusions:

  • The TP63/microRNA network is a key player in epithelial cancer development, progression, and chemoresistance.
  • This network regulates critical cellular functions such as cell cycle arrest, apoptosis, autophagy, metabolism, and epigenetic transcriptional regulation.
  • Targeting the TP63/microRNA network presents promising avenues for novel cancer chemotherapeutic interventions.
Keywords:
ApoptosisAutophagyCell cycle arrestCell metabolismChemoresistanceEpigeneticsTP63.microRNA

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