Related Experiment Video

Updated: May 4, 2026

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques
11:28

Dried Blood Spots - Preparing and Processing for Use in Immunoassays and in Molecular Techniques

Published on: March 13, 2015

46.1K

Frequency of HCV infection in different dermatological disorders

Atiya Rahman1, Syed Dilawar Abbas Rizvi2, Zafar Iqbal Sheikh2

  • 1Department of Dermatology, Combined Military Hospital, Malir Cantt, Karachi, Pakistan. atiya_rahman7@yahoo.com

Journal of Ayub Medical College, Abbottabad : JAMC
|January 9, 2014
PubMed

Insights

Hepatitis C Virus (HCV) infection is more common in patients with certain skin conditions like lichen planus and porphyria cutanea tarda. However, conditions such as leukocytoclastic vasculitis showed no association with HCV.

Area of Science:

  • Hepatology
  • Dermatology
  • Infectious Diseases

Background:

  • Hepatitis C Virus (HCV) affects approximately 3% of the global population, with higher prevalence noted in Pakistan.
  • Dermatological disorders are sometimes linked to HCV infection, necessitating further investigation into these associations.

Purpose of the Study:

  • To investigate the frequency of Hepatitis C Virus (HCV) infection among patients presenting with various dermatological disorders.
  • To identify specific skin conditions associated with a higher prevalence of HCV.

Main Methods:

  • A descriptive study was conducted from September 2003 to November 2005.
  • 355 patients with specific dermatological disorders were enrolled from Military Hospital, Rawalpindi, and PNS Shifa, Karachi.
  • Hepatitis C Virus (HCV) infection status was determined by detecting anti-HCV antibodies using third-generation ELISA.

Main Results:

  • HCV infection was found in 14% of lichen planus, 8% of generalized pruritus, 7.8% of urticaria, 8.7% of prurigo, and 50% of porphyria cutanea tarda patients.
  • No anti-HCV antibodies were detected in patients with leukocytoclastic vasculitis, erythema multiforme, or erythema nodosum.
  • No cases of mixed cryoglobulinemia or polyarteritis nodosa were observed during the study period.

Conclusions:

  • Patients with lichen planus, generalized pruritus, urticaria, prurigo, and porphyria cutanea tarda exhibit a higher frequency of HCV infection compared to the general population in Pakistan.
  • Leukocytoclastic vasculitis, erythema multiforme, and erythema nodosum were not associated with HCV infection in this study cohort.
Abstract

More Related Videos

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis10:23

Lipid Droplet Isolation for Quantitative Mass Spectrometry Analysis

Published on: April 17, 2017

9.9K
Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation08:04

Development of an IFN-γ ELISpot Assay to Assess Varicella-Zoster Virus-specific Cell-mediated Immunity Following Umbilical Cord Blood Transplantation

Published on: July 9, 2014

14.5K

Related Concept Videos

Hepatitis01:25

Hepatitis

Hepatitis is an inflammatory condition of the liver most commonly caused by hepatotropic viruses (A–E), though non-infectious causes such as alcohol and drugs also exist.Hepatitis AHepatitis A virus (HAV) is a non-enveloped RNA virus of the Picornaviridae family. It is primarily transmitted via the fecal-oral route, typically through ingestion of contaminated food or water. After ingestion, HAV enters the bloodstream through the oropharynx or intestinal epithelium and reaches the liver.
86
Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
5.4K
Viral Hepatitis I: Introduction01:28

Viral Hepatitis I: Introduction

Viral hepatitis is an inflammatory condition of the liver caused by infection with hepatotropic viruses, most commonly hepatitis A, B, C, D, and E. Despite variations in structure and transmission, all viruses mentioned infect hepatocytes and provoke immune responses that can hinder liver function. Additionally, some non-hepatotropic viruses can also lead to hepatic inflammation.Hepatitis A VirusHepatitis A virus (HAV) is transmitted through the fecal–oral route, typically by ingestion...
25
Cytomegalovirus Disease01:27

Cytomegalovirus Disease

Cytomegalovirus (CMV) disease is caused by human cytomegalovirus, a double-stranded DNA virus of the Herpesviridae family. While primary CMV infection is often asymptomatic in immunocompetent individuals, the virus can cause severe disease in neonates and immunocompromised patients. CMV is the most common cause of congenital viral infection in the United States, and a major pathogen in solid organ and hematopoietic stem cell transplant recipients.CMV is transmitted via bodily fluids, sexual...
102
Infectious Diseases and Their Occurrence01:28

Infectious Diseases and Their Occurrence

Infectious diseases appear in populations through various transmission patterns, influenced by pathogen characteristics, population immunity, environmental conditions, and social behavior. Understanding these patterns is essential for effective public health surveillance and intervention. These categories—sporadic, outbreak, epidemic, pandemic, and endemic—help frame the nature and scope of disease events.Sporadic diseases occur irregularly and infrequently, without a predictable...
94
Diseases of the Liver and Gallbladder01:26

Diseases of the Liver and Gallbladder

Liver and gallbladder diseases are a significant health concern, with prominent conditions including cirrhosis, hepatitis, non-alcoholic fatty liver disease (NAFLD), and gallstones. Jaundice is a common manifestation of liver and biliary disease.
Cirrhosis is characterized by the scarring of hepatic lobules in the liver, which are replaced by fibrous tissue, affecting the liver's normal functioning. NAFLD, on the other hand, is caused by an excessive build-up of fat in the liver, not...
2.1K