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Femtogram detection of cytokines in a direct dot-blot assay using SERS microspectroscopy and hydrophilically
Yuling Wang1, Mohammad Salehi, Max Schütz
1Faculty of Chemistry and Center for Nanointegration Duisburg-Essen (CENIDE), University of Duisburg-Essen, Universitaetsstr. 5, D-45141 Essen, Germany. sebastian.schluecker@uni-due.de.
Chemical Communications (Cambridge, England)
|January 9, 2014
Abstract:
Rapid parallel detection of two cytokines (IL-6 and IL-8) with femtogram sensitivity in a simple direct dot-blot assay is demonstrated. The microspectroscopic SERS acquisition scheme employs rationally designed, hydrophilically stabilized Au-Ag nanoshells as SERS labels, which are optimized for signal enhancement upon red laser excitation.
