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Updated: May 4, 2026
Stabilizing Hepatocellular Phenotype Using Optimized Synthetic Surfaces
Published on: September 26, 2014
Enhanced hepatoprotective activity of andrographolide complexed with a biomaterial
Amol D Thingale1, Karimunnisa S Shaikh, Prajakta R Channekar
1Department of Pharmaceutics, Modern College of Pharmacy , Yamunanagar, Pune, Maharashtra , India and.
Context:
Humic acid (HA), a natural organic matter is recently being investigated for pharmaceutical purposes. Andrographolide (AGP), a potent hepatoprotective, possesses low aqueous solubility which results in a low bioavailability after oral administration, inappropriate tissue localization and consequently poor therapeutic application.
Objective:
The present study investigates the complexation of AGP with HA to increase its solubility and hepatoprotective efficacy.
Materials And Methods:
Complexes prepared by solvent evaporation in various weight ratios were characterized using differential scanning calorimetry, Fourier Transform InfraRed spectroscopy, X-ray diffraction, and scanning electron microscopy.
Results And Discussion:
The complexed AGP demonstrated improved solubility, dissolution, and permeation across rat intestine. It also displayed better hepatoprotection against carbontetrachloride-induced liver toxicity than the free drug in rats.
Conclusion:
Complexation with HA is a valuable technique to improve solubility and bioavailability of pharmaceuticals.
