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Intratracheal Administration of Dry Powder Formulation in Mice
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In Vitro and In Vivo Performance of Novel Spray Dried Andrographolide Loaded Scleroglucan Based Formulation for Dry
Ashwin Jagannath Mali, Chellampillai Bothiraja, Ravindra Nandlal Purohit
1Department of Pharmaceutics, Poona College of Pharmacy, Bharati Vidyapeeth University, Erandwane, Pune- 411038, Maharashtra, India
Current Drug Delivery
|November 12, 2016
Summary
A novel spray-dried formulation of andrographolide (AGP) and scleroglucan (SCLG) enhances lung deposition and pulmonary antihypertensive activity, offering a promising new treatment for pulmonary arterial hypertension (PAH).
Area of Science:
- Pharmaceutical Sciences
- Pharmacology
- Biomaterials Science
Background:
- Current pulmonary arterial hypertension (PAH) therapies face limitations in preventing disease progression.
- Existing treatments often involve continuous infusions or multiple oral administrations.
- There is a critical need for novel treatments targeting vascular changes in PAH.
Purpose of the Study:
- To develop a spray-dried (SD) formulation for dry powder inhaler (DPI) delivery.
- To enhance aerosol performance and lung deposition using andrographolide (AGP) and scleroglucan (SCLG).
- To evaluate the antihypertensive activity of the novel SDAGP formulation.
Main Methods:
- Spray drying technique was employed to create the SDAGP formulation.
- Physicochemical properties, in vitro/in vivo lung deposition were assessed.
- Antihypertensive activity was evaluated in a monocrotaline (MCT)-induced rat model.
Main Results:
- The SDAGP formulation achieved a mean median aerodynamic diameter (MMAD) of 3.37 ± 0.47 µm and a fine particle fraction (FPF) of 60.24 ± 0.98%.
- In vivo studies demonstrated increased AGP lung deposition within 24 hours, with no observed inflammation or toxicity.
- The SDAGP formulation exhibited enhanced antihypertensive activity.
Conclusions:
- Andrographolide (AGP) and scleroglucan (SCLG) serve as effective novel bioactive and carrier components.
- The developed formulation significantly improves lung deposition of AGP.
- The study confirms enhanced pulmonary antihypertensive activity of the novel formulation.
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