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Expression of matrix metalloproteinases in patients with bipolar disorder

Fábria Chiarani1, Gabriel Rodrigo Fries1, Laura Stertz1

  • 1Molecular Psychiatry Unit and National Science and Technology Institute for Translational Medicine (INCT-TM), Hospital de Clínicas de Porto Alegre (HCPA), Universidade Federal do Rio Grande do Sul (UFRGS), Porto AlegreRS, Brazil.

Revista Brasileira De Psiquiatria (Sao Paulo, Brazil : 1999)
|January 10, 2014
PubMed
Abstract

Insights

Matrix metalloproteinases (MMPs) like MMP-2 and MMP-9 show no difference in expression in bipolar disorder (BD) patients versus controls. However, MMP-2 levels correlate differently with body mass index (BMI) in BD patients compared to healthy individuals.

Area of Science:

  • Biochemistry
  • Psychiatry
  • Cardiovascular Medicine

Background:

  • Patients with bipolar disorder (BD) exhibit elevated cardiovascular mortality.
  • Matrix metalloproteinases (MMPs), specifically MMP-2 and MMP-9, are recognized contributors to cardiovascular diseases.
  • Understanding the role of MMPs in BD is crucial for addressing associated cardiovascular risks.

Purpose of the Study:

  • To investigate the expression patterns of MMP-2 and MMP-9 in individuals with bipolar disorder (BD).
  • To compare MMP expression in BD patients during acute mania and euthymia against healthy controls.
  • To explore the relationship between MMP expression and body mass index (BMI) in BD patients.

Main Methods:

  • Recruitment of 20 BD patients and 20 age- and sex-matched healthy controls.
  • Quantification of MMP-2 and MMP-9 messenger RNA (mRNA) levels using real-time quantitative polymerase chain reaction (PCR).
  • Calculation of body mass index (BMI) for all participants.

Main Results:

  • No significant differences were observed in MMP-2 and MMP-9 mRNA expression between BD patients and controls.
  • MMP mRNA levels did not differ significantly between manic and euthymic states in BD patients.
  • MMP-2 mRNA levels showed a negative association with BMI in BD patients, contrasting with a positive association in controls. MMP-9 expression patterns were similar between groups.

Conclusions:

  • The association between MMP-2 and BMI differs between bipolar disorder patients and healthy individuals.
  • Further research into the role of MMPs in bipolar disorder is warranted to clarify their connection to cardiovascular risk.
  • Investigating MMPs may offer insights into managing cardiovascular complications in BD.

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