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Nanofilaments on glioblastoma exosomes revealed by peak force microscopy
Shivani Sharma1, Kingshuk Das, JungReem Woo
1Department of Chemistry and Biochemistry, University of California, , Los Angeles, CA 90095, USA.
Journal of the Royal Society, Interface
|January 10, 2014
Abstract:
Exosomes are sub-100 nm extracellular vesicles secreted by normal and cancer cells. We present a high-resolution structure of previously unidentified nanofilaments on glioblastoma-derived exosomes, using nanoscale peak force imaging. These stiff, adhesive, trypsin- and RNAse-resistant surface nanofilaments add a new dimension to the current structural knowledge of exosome-mediated intercellular communication.

