PET-Negative Gastrointestinal Stromal Tumors
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Updated: May 4, 2026

Molecular and Immunologic Techniques in a Genetically Engineered Mouse Model of Gastrointestinal Stromal Tumor
Published on: May 2, 2022
Anja Williams1, Andreas Gutzeit2, Michael Germer3
1Department of Oncology, Kantonsspital Winterthur, Winterthur, Chur, Switzerland.
Abstract:
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal malignancy of the gastrointestinal tract. PET/CT is a common diagnostic tool and is also used for therapy monitoring. GISTs typically show strong (18)F-fluorodeoxyglucose (FDG) uptake. Here we present two cases of GIST with unusually low/negative FDG uptake. FDG negativity does not preclude the diagnosis of a GIST.
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