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Kinetic Screening of Nuclease Activity using Nucleic Acid Probes
Published on: November 1, 2019
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Nucleic Acid aptamers: new methods for selection, stabilization, and application in biomedical science.
Hoon Young Kong1, Jonghoe Byun1
1Department of Molecular Biology, Institute of Nanosensor and Biotechnology, Dankook University, Yongin 448-701, Republic of Korea.
Biomolecules & Therapeutics
|January 10, 2014
Summary
Oligonucleotide aptamers, selected via SELEX, offer versatile biomedical applications due to their high specificity and advantages over antibodies. Novel technologies enhance aptamer modification and conjugation for drug delivery and molecular imaging.
Area of Science:
- Biochemistry
- Molecular Biology
- Biotechnology
Background:
- Oligonucleotide aptamers are increasingly used in biomedicine for their versatility.
- Aptamers are single-stranded nucleic acids that fold into specific 3D structures for molecular recognition.
- They offer advantages over antibodies, including thermal stability, ease of synthesis, and low immunogenicity.
Purpose of the Study:
- To discuss new SELEX strategies and aptamer stabilization methods.
- To explore emerging aptamer applications in drug delivery and molecular imaging.
Main Methods:
- SELEX (Systematic Evolution of Ligands by EXponential enrichment) is used to obtain specific aptamers.
- Aptamers can be chemically modified and conjugated to various molecules.
- Novel technologies are revolutionizing aptamer development and application.
Main Results:
- Aptamers exhibit high affinity and specificity for molecular targets.
- Chemical modifications and conjugations expand aptamer functionalities.
- Advanced SELEX strategies and stabilization techniques improve aptamer utility.
Conclusions:
- Aptamers are powerful tools in biomedical research and applications.
- Ongoing technological advancements promise to further enhance aptamer capabilities in drug delivery and imaging.
- The unique properties of aptamers position them as valuable alternatives to antibodies in various fields.
