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Immune response to mutant neo-antigens: Cancer's lessons for aging
Rory J Geyer1, Rebecca Tobet1, Richard D Berlin1
1Department of Immunology; University of Connecticut School of Medicine; Farmington, CT USA ; Carole and Ray Neag Comprehensive Cancer Center; University of Connecticut School of Medicine; Farmington, CT USA.
Abstract:
Extending observations on the immunogenicity of neo-antigens that arise in the course of oncogenesis and tumor progression, we suggest that somatic mutations affecting normal tissues also lead to generation of new epitopes. We hypothesize that, at least under inflammatory conditions, immune responses against such neo-antigens may lead to the elimination or functional impairment of normal cells, thus contributing to aging.
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