Conductive polymer nanotube patch for fast and controlled ex vivo transdermal drug delivery
Thao M Nguyen1, Sebin Lee, Sang Bok Lee
1Department of Chemistry & Biochemistry, University of Maryland, College Park, MD 20742, USA. slee@umd.edu.
Aim:
To uptake and release hydrophilic model drugs and insulin in a novel conductive polymer (CP) nanotube transdermal patch.
Materials & Methods:
The externally controlled transdermal delivery of model drugs and insulin were tested ex vivo and results were compared with CP films. The unique intrinsic properties of CPs provide electrostatic interaction between the model drugs and polymer backbone.
Results & Discussion:
When a pulsed potential was applied, the drug delivery release profile mimics that of injection delivery. With a constant potential applied, the release rate constants of the patch system were up to three-times faster than the control (0 V) and released approximately 80% more drug molecules over 24 h.
Conclusion:
The CP nanotube transdermal patch represents a new and promising drug method, specifically for hydrophilic molecules, which have been a large obstacle for conventional transdermal drug delivery systems.
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