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Related Concept Videos

Endocytosis01:16

Endocytosis

10.6K
Eukaryotic cells acquire nutrients for growth and proliferation. Nutrients and other molecules that require degradation are internalized from the extracellular space by a process called endocytosis. The term ‘endocytosis' was first coined by Christian de Duve in 1963.
Endocytosis always begins with the plasma membrane enclosing an incoming molecule to form a transport vesicle which, in some cases, can be coated with a protein called ‘clathrin.' Endocytosed material is either...
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Receptor-mediated Endocytosis01:20

Receptor-mediated Endocytosis

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Receptor-mediated endocytosis is when bulk amounts of specific molecules are imported into a cell after binding to cell surface receptors. The molecules bound to these receptors are taken into the cell through inward folding of the cell surface membrane, which is eventually pinched off into a vesicle within the cell. Structural proteins, such as clathrin, coat the budding vesicle.
Clathrin-Mediated Endocytosis of LDL
One well-characterized example of receptor-mediated endocytosis is the...
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Receptor-Mediated Endocytosis01:20

Receptor-Mediated Endocytosis

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Receptor-mediated Endocytosis01:38

Receptor-mediated Endocytosis

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Overview
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Maturation of Endosomes01:28

Maturation of Endosomes

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The early endosome containing internalized molecules matures through transformations in its location, morphology, intraluminal pH, and membrane protein composition. Together, these changes result in a more acidic late endosome that contains multiple intraluminal vesicles; therefore, the late endosome is also called a multivesicular body (MVB).
Changes in location
The maturing endosome moves along microtubules from the periphery of the cell towards the perinuclear region. This movement of the...
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The Early Endosome: Endocytosis of Transferrin01:28

The Early Endosome: Endocytosis of Transferrin

4.1K
Essential proteins such as insulin or low-density lipoprotein (LDL) and micronutrients such as iron enter a eukaryotic cell through receptor-mediated endocytosis. Subsequently, the early endosomes fuse with the vesicles containing such receptor-ligand complexes and play a vital role in sorting the incoming ligands and receptors. While the ligands are either degraded inside the vesicle or released into the cytosol, their receptors are returned to the plasma membrane for further rounds of...
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Related Experiment Video

Updated: May 4, 2026

Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast
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Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast

Published on: October 23, 2016

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Systems dynamics in endocytosis.

Maximilian Fürthauer1, Elizabeth Smythe

  • 1Institut de Biologie Valrose, CNRS UMR7277, INSERM 1091, University of Nice Sophia-Antipolis, Nice, France.

Traffic (Copenhagen, Denmark)
|January 11, 2014
PubMed
Summary

Researchers explored the endolysosomal system

Area of Science:

  • Cell Biology
  • Molecular Biology
  • Biophysics

Background:

  • The endocytic system is crucial for cell signaling and membrane dynamics.
  • Endolysosomal organelles are vital for cellular functions.
  • Understanding the endomembrane system is key to cellular information processing.

Purpose of the Study:

  • To present the latest findings on the endolysosomal system.
  • To identify future challenges in endolysosomal research.
  • To integrate diverse research approaches for a comprehensive view.

Main Methods:

  • Biochemical and cell biological approaches.
  • Quantitative biophysics.
  • Systems biology and animal model systems.
Keywords:
endocytosislipidsmembrane dynamicssignalingsystems biology

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Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy

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Probing Structural and Dynamic Properties of Trafficking Subcellular Nanostructures by Spatiotemporal Fluctuation Spectroscopy
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Applications of pHluorin for Quantitative, Kinetic and High-throughput Analysis of Endocytosis in Budding Yeast
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Visualizing Clathrin-mediated Endocytosis of G Protein-coupled Receptors at Single-event Resolution via TIRF Microscopy
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Main Results:

  • Covered cellular mechanics of endocytosis.
  • Discussed protein and lipid roles in organelle biogenesis and function.
  • Analyzed higher-order system properties in multicellular contexts.

Conclusions:

  • Highlighted the integration of multiple disciplines.
  • Emphasized the need for quantitative and systems-level analysis.
  • Aimed for an integrated view of the endomembrane system's properties and cellular roles.