Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Satellite Stem Cells and Muscular Dystrophy01:21

Satellite Stem Cells and Muscular Dystrophy

1.7K
Satellite stem cells or myosatellite cells are quiescent stem cells that Alexander Mauro first identified in 1961. These cells are located between the sarcolemma, the plasma membrane of muscle fibers, and the basal lamina, the connective tissue sheath covering it. These mononucleated cells are activated in response to muscle injury, can transform into myoblasts, and may form or repair muscle fibers. Myosatellite cells can provide additional myonuclei for muscle regeneration or return to a...
1.7K
Disorders of the Skeletal Muscle01:28

Disorders of the Skeletal Muscle

2.2K
The clinical conditions affecting the skeletal muscle tissue are broadly categorized as musculoskeletal and neuromuscular disorders.
Musculoskeletal disorders
Musculoskeletal disorders involve injuries and conditions affecting the skeletal muscles and associated connective tissues. These disorders can arise from acute biomechanical stresses or chronic overuse and can occur across different age groups. Common injuries include sprains, fractures, and muscular strains, often resulting from...
2.2K
Somatic Spinal Reflexes01:22

Somatic Spinal Reflexes

7.8K
Somatic spinal reflexes are rapid, involuntary muscular responses to external stimuli that involve the somatic musculature and the spinal cord.
One of the most well-known somatic spinal reflexes is the stretch reflex, which is activated by the sudden stretching of a muscle. This reflex involves the activation of specialized sensory receptors called muscle spindles, which are located in the muscle tissue and detect changes in the length and speed of muscle contractions. When a muscle is suddenly...
7.8K
Classification of Skeletal Muscle Relaxants01:28

Classification of Skeletal Muscle Relaxants

3.6K
Skeletal muscle relaxants are a group of drugs that can reduce muscle stiffness and induce temporary paralysis to relieve pain. These agents can act centrally to reduce muscle tone or spasms in painful conditions such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS), or spinal injuries; they are called antispasmodics or spasmolytics.
Peripherally acting skeletal muscle relaxants interfere with the neurotransmission at the neuromuscular end plate to induce paralysis during...
3.6K
Myasthenia Gravis: Diagnostic Tests01:15

Myasthenia Gravis: Diagnostic Tests

3.3K
Myasthenia gravis is an autoimmune condition affecting neuromuscular transmission, causing generalized weakness in skeletal muscles. Initial diagnoses rely on patients' signs, symptoms, and medical history. The challenge lies in distinguishing myasthenia from other muscular dystrophies. An important diagnostic feature is the significant improvement of symptoms after administering anticholinesterase inhibitors.
The edrophonium test is a diagnostic tool for myasthenia gravis. It involves...
3.3K
Skeletal Muscle Relaxants: Therapeutic Uses01:31

Skeletal Muscle Relaxants: Therapeutic Uses

1.2K
Skeletal muscle relaxants are used to relax muscle tone and alleviate painful muscle contractions. However, the choice of skeletal muscle relaxants depends on the duration of the surgical procedure in order to minimize potential side effects. Skeletal muscle relaxants like neuromuscular blocking agents [NMBAs] are commonly employed as adjuvants alongside general anesthetics in clinical settings. NMBAs are also used to maintain controlled ventilation during surgery of the larynx or pharynx...
1.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Role of diffusion-weighted magnetic resonance imaging and apparent diffusion coefficient in subtyping renal cell carcinoma.

World journal of radiology·2026
Same author

Reply to: In DeFi-ance of "More Is Better": Questioning Long-Term Nirogacestat Use in Desmoid Tumors.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology·2026
Same author

A silent aggressor: disseminated histoplasmosis with laryngeal and adrenal involvement in a diabetic patient.

Endocrinology, diabetes & metabolism case reports·2026
Same author

DICER1-mutated renal neoplasia: A series of 5 cases demonstrating the spectrum of cystic nephroma, Wilms tumor, and anaplastic sarcoma.

Human pathology·2026
Same author

Renal elasticity assessment in patients of glomerulonephritis by shear-wave elastography and its correlation with histopathology and renal biomarkers.

World journal of nephrology·2026
Same author

Multi-Targeted TKIs in Patients with Advanced Ewing Sarcoma: A Systematic Review and Single-Arm Meta-Analysis.

Cancers·2026

Related Experiment Video

Updated: May 4, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

983

Diffuse skeletal muscle metastases from sacral chordoma.

Kathleen Carey1, Joseph Bestic, Steven Attia

  • 1Department of Radiology, Mayo Clinic, 4500 San Pablo Road South, Jacksonville, FL, 32224, USA.

Skeletal Radiology
|January 11, 2014
PubMed
Summary

Metastatic chordoma, a rare bone cancer, can spread to skeletal muscle, which is exceptionally uncommon. This case highlights extensive multifocal muscle metastases from recurrent sacral chordoma, with only one prior report of muscle metastasis.

More Related Videos

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.2K

Related Experiment Videos

Last Updated: May 4, 2026

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice
05:39

Surgical Transplantation of Tumor Cells into the Spinal Cord of Mice

Published on: December 27, 2024

983
Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors
08:57

Author Spotlight: Genetically Engineered Mouse Models and Pathological Characterization of Neurofibromatosis Type 1 Associated Tumors

Published on: May 17, 2024

3.1K
Comparative Lesions Analysis Through a Targeted Sequencing Approach
08:16

Comparative Lesions Analysis Through a Targeted Sequencing Approach

Published on: November 5, 2019

6.2K

Area of Science:

  • Oncology
  • Pathology
  • Skeletal Tumors

Background:

  • Chordomas are rare, slow-growing malignant bone tumors originating from notochordal remnants.
  • They predominantly affect the axial skeleton, with the sacrum being the most common site.
  • While local recurrence is typical, chordoma metastasis occurs in 10-42% of cases.

Observation:

  • This report details a rare instance of extensive, multifocal skeletal muscle metastases.
  • The metastases developed in a patient with recurrent sacral chordoma.
  • Literature review identified only one prior case of chordoma metastasis to skeletal muscle.

Findings:

  • Skeletal muscle metastasis from chordoma is an exceedingly rare phenomenon.
  • Extensive and multifocal muscle involvement, as seen in this case, is unprecedented.
  • Chordoma can disseminate to diverse organ systems, including soft tissues.

Implications:

  • This case expands the known spectrum of chordoma metastatic patterns.
  • It underscores the importance of considering unusual metastatic sites in chordoma patients.
  • Further research is needed to understand the mechanisms and clinical significance of muscle metastasis in chordoma.