Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Aneurysm III: Interprofessional Care

Aneurysm III: Interprofessional Care

Aneurysm management involves either conservative medical therapy or surgical intervention, depending on the size and symptoms of the aneurysm. Conservative management is generally reserved for smaller, asymptomatic aneurysms, while larger or symptomatic aneurysms often necessitate surgical repair.Conservative Medical TherapyFor small, asymptomatic aneurysms, particularly abdominal aortic aneurysms (AAA) less than 5.5 centimeters in diameter, conservative medical therapy is recommended. This...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Defining Social and Cultural Barriers to Global Stroke Care: A SVIN-Mission Thrombectomy Initiative.

Stroke (Hoboken, N.J.)·2026

Same author

Unveiling the complexity of post-Roman polity formation in Pannonia using ancient DNA.

Science (New York, N.Y.)·2026

Same author

Clinical and haemodynamic outcomes with contemporary intra- and supra-annular self-expanding valves: the multicentre international HERA-TAVI registry.

EuroIntervention : journal of EuroPCR in collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·2026

Same author

Transcending Social and Cultural Barriers to Transform Global Stroke Care: An SVIN Mission Thrombectomy Initiative.

Stroke (Hoboken, N.J.)·2026

Same author

Final results of the Ruptured Aneurysms treated with HydroGEl Coils (RAGE) study: a multicenter study of 771 patients.

Journal of neurointerventional surgery·2026

Same author

Multiplexed Tandem Mass Spectrometry Imaging Enables Large-Scale Isomer Mapping and Annotation in Tissues.

Angewandte Chemie (International ed. in English)·2026

Search research articles

Related Experiment Video

Updated: May 4, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

Intra-aneurysmal superselective pharmacologic testing in a child.

Gabor Toth¹, Jonathan A White², G Lee Pride²

¹Cerebrovascular Center, Cleveland Clinic, Cleveland, OH, USA.

Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia

|January 14, 2014

Summary

This summary is machine-generated.

This study details a novel approach for treating a complex brain aneurysm in a child using superselective intra-aneurysmal provocative testing. The successful endovascular coiling preserved neurological function, offering a new treatment option for challenging cases.

Keywords:

Amobarbital Cerebral aneurysm Endovascular Pharmacologic testing Superselective

More Related Videos

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Published on: July 9, 2020

Related Experiment Videos

Last Updated: May 4, 2026

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Testing Acetylcholine Followed by Adenosine for Invasive Diagnosis of Coronary Vasomotor Disorders

Published on: February 3, 2021

A Novel Method: Super-selective Adrenal Venous Sampling

A Novel Method: Super-selective Adrenal Venous Sampling

Published on: September 15, 2017

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

A Rat Carotid Artery Pressure-Controlled Segmental Balloon Injury with Periadventitial Therapeutic Application

Published on: July 9, 2020

Area of Science:

Neurology
Vascular Surgery
Pediatric Neurosurgery

Background:

Complex intracranial aneurysms with branch vessels pose treatment challenges due to their proximity to critical brain areas.
Limited treatment options exist for pediatric intracranial aneurysms involving eloquent territory perforator vessels.

Observation:

A 9-year-old boy presented with a recurrent proximal middle cerebral artery aneurysm.
Provocative functional testing using sodium amobarbital was performed via superselective microcatheter injection into the aneurysm and a lenticulostriate vessel.

Findings:

No new neurological deficits were observed after provocative testing.
Successful endovascular coiling of the aneurysm was achieved with sacrifice of the involved perforator vessel.
The patient remained neurologically intact with no aneurysm recurrence on angiography.

Implications:

This case demonstrates the youngest patient to undergo superselective intra-aneurysmal provocative testing for a proximal intracranial aneurysm.
This technique offers a viable and safe endovascular treatment strategy for complex pediatric intracranial aneurysms involving perforator vessels.
Successful management highlights the potential for preserving neurological function in challenging neurovascular cases.