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Time-resolved ElectroSpray Ionization Hydrogen-deuterium Exchange Mass Spectrometry for Studying Protein Structure and Dynamics
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Indirect use of deuterium in solution NMR studies of protein structure and hydrogen bonding

Vitali Tugarinov1

  • 1Department of Chemistry and Biochemistry, University of Maryland, College Park, MD 20742, United States.

Progress in Nuclear Magnetic Resonance Spectroscopy
|January 14, 2014
PubMed

Keywords:
BIRDCPMGCSACarr–Purcell–Meiboom–Gill pulse trainDeuterationDeuterium isotope shiftsHydrogen bondsMSGMalate Synthase GNOEProtein backbone geometryProtein dynamicsQCCRDCSpin relaxation in deuterium-containing spin-systemsTROSYbilinear rotation decouplingchemical shift anisotropynuclear Overhauser effectquadrupolar coupling constantresidual dipolar couplingtransverse relaxation optimized spectroscopy

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