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Anti-N-methyl-aspartate receptor encephalitis in identical twin sisters: role for oophorectomy
Salome Masghati1, Mana Nosratian, Oliver Dorigo
1Department Obstetrics and Gynecology, UCLA David Geffen School of Medicine, Los Angeles, and the Department Obstetrics and Gynecology, Division of Gynecologic Oncology, Stanford School of Medicine, Stanford, California.
Background:
Anti-N-methyl-aspartate receptor encephalitis is a potentially fatal form of encephalitis and frequently associated with ovarian teratomas. Surgical removal of ovarian teratomas improves clinical outcome, but it is unclear whether bilateral salpingo-oophorectomy for normal-appearing ovaries is of clinical benefit.
Case:
Our report describes a unique clinical scenario of identical twin sisters with anti-N-methyl-aspartate receptor encephalitis. Neither patient responded to immunosuppressive therapy. Imaging studies showed normal-appearing ovaries. The first twin continued on medical therapy only and died of the disease. The second twin underwent a bilateral salpingo-oophorectomy followed by gradual recovery.
Conclusion:
Based on our experience in two genetically identical individuals, we suggest considering the removal of normal-appearing ovaries in patients with anti-N-methyl-aspartate receptor encephalitis who fail to respond to medical treatment.
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