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[Mycobacterium ulcerans disease (Buruli ulcer) in Gabon: 2005-2011]
L S Bayonne Manou1, F Portaels2, M Eddyani2
1Ministère de la Santé publique, BP 5258 Libreville, Gabon.
Medecine Et Sante Tropicales
|January 14, 2014
Summary
Buruli ulcer (BU) is endemic in Gabon, with most confirmed cases along the Ogooué River. Early diagnosis and treatment are crucial for managing this public health problem.
Area of Science:
- Neglected tropical diseases
- Mycobacterial infections
- Epidemiology
Context:
- Buruli ulcer (BU) cases have been documented in Gabon since the 1960s.
- A significant number of suspected BU cases were identified across Gabon between 2005 and 2011.
- Microbiological confirmation using Polymerase Chain Reaction (PCR) was employed to validate suspected cases.
Purpose:
- To determine the prevalence and geographical distribution of Buruli ulcer in Gabon.
- To characterize the clinical and epidemiological features of BU patients in Gabon.
- To assess the diagnostic accuracy of PCR in identifying Mycobacterium ulcerans and to evaluate treatment outcomes.
Summary:
- Out of 301 suspected cases, 120 (39.9%) tested positive for Mycobacterium ulcerans via PCR.
- Confirmed BU cases were predominantly found in the Moyen-Ogooué province, particularly along the Ogooué River.
- PCR-negative cases presented different demographic and lesion characteristics, highlighting the need for differential diagnosis. The cure rate for confirmed BU cases was 88% using WHO-recommended antibiotics.
Impact:
- This study confirms Buruli ulcer as an endemic public health issue in Gabon.
- Late patient presentation with extensive lesions necessitates enhanced awareness campaigns for earlier detection and treatment.
- Further research into the influence of HIV on Buruli ulcer in Gabon is warranted.
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