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Updated: May 4, 2026

Embryonic Stem Cell-Derived Endothelial Cells for Treatment of Hindlimb Ischemia
Published on: January 23, 2009
The current state of stem cell therapy for peripheral artery disease
Nitin K Gupta1, Ehrin J Armstrong, Sahil A Parikh
1Division of Cardiovascular Medicine, Harrington Heart & Vascular Institute, University Hospitals Case Medical Center, 11000 Euclid Ave., LKS 5038, Cleveland, OH, 44106, USA, nitin.gupta@uhhospitals.org.
Abstract:
Patients with advanced peripheral arterial disease may develop critical limb ischemia with rest pain, non-healing ulcerations, and eventually may require major amputation despite currently available revascularization technologies. Stem cell therapies hold promise as novel therapeutics to promote vasculogenesis and improve tissue perfusion in these patients. This article reviews the current state of stem cell therapy for patients with peripheral arterial disease, with a focus on the cell types that have been studied, barriers to clinical development, and development of new endpoints for clinical trials.
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