Related Experiment Video
Updated: May 4, 2026

Identification of OTX1 and OTX2 As Two Possible Molecular Markers for Sinonasal Carcinomas and Olfactory Neuroblastomas
Published on: February 28, 2019
Genetic contributors to otitis media: agnostic discovery approaches
E Kaitlynn Allen1, Ani Manichaikul, Michèle M Sale
1Center for Public Health Genomics, University of Virginia, PO Box 800717, Charlottesville, VA, 22908, USA.
Abstract:
Otitis media (OM) is the most common disease in children in the United States, with about $5 billion spent each year in direct and indirect costs. OM is the number one reason for pediatric antibiotic usage and surgery, although treatment options are limited. Numerous studies have established the high heritability of OM and a genetic contribution to OM pathogenesis. Candidate gene studies have highlighted the roles of inflammation, mucin secretion, and pathogen recognition, but this approach is unable to identify novel pathways to target for treatment or screening purposes. Here, we review the current literature on agnostic approaches to discover novel genes and pathways involved in OM pathogenesis.
More Related Videos
Related Concept Videos
Genome Size and the Evolution of New Genes
Genetic Lingo
Mechanism of Antibiotic Resistance in MRSA
Modern Molecular Taxonomy
Single Nucleotide Polymorphisms-SNPs
Pharmacogenomics: Identification of New Drug Targets

