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Updated: May 4, 2026

Biochemical Reconstitution of Steroid Receptor•Hsp90 Protein Complexes and Reactivation of Ligand Binding
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Interaction of JAK with steroid receptor function

Nibedita Gupta1, Doris Mayer2

  • 1Hematology and Oncology; University Hospital Magdeburg; Magdeburg, Germany.

JAK-STAT
|January 14, 2014
PubMed

Insights

This review explores the crucial cross-talk between Janus Kinase (JAK) signaling and steroid receptors. Aberrant JAK-steroid receptor interactions are implicated in diseases like cancer.

Area of Science:

  • Molecular Biology
  • Cell Signaling
  • Endocrinology

Background:

  • Steroid receptor function is modulated by hormones and cellular signaling pathways.
  • Membrane-bound receptors, activated by growth factors or cytokines, influence steroid receptor activity.
  • Cross-talk between Janus Kinase (JAK) and steroid receptors is vital for physiological regulation.

Purpose of the Study:

  • To summarize current knowledge on JAK and steroid receptor interactions.
  • To discuss these interactions in normal physiological contexts and disease states.
  • To highlight the role of aberrant signaling in disease development, including cancer.

Main Methods:

  • Literature review of existing research on JAK-steroid receptor signaling.
  • Analysis of studies investigating normal cellular and tissue functions.
  • Examination of research linking aberrant signaling to disease pathogenesis.

Main Results:

  • JAK signaling pathways significantly impact steroid receptor activity.
  • Dysregulation of this cross-talk is linked to various diseases.
  • Specific examples of these interactions in normal physiology and pathology are discussed.

Conclusions:

  • The interplay between JAK and steroid receptors is a key regulatory mechanism.
  • Aberrant signaling contributes to the development and progression of diseases like cancer.
  • Further research into these interactions may reveal therapeutic targets.
Keywords:
JAK2/estrogen receptor-alpha interactionPPAR ligandsaldosteroneandrogensestrogensglucocorticoidsprogesteroneretinoic acidvitamin D

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