[Progress on the relationship between wear debris-induced apoptosis and aseptic loosening of prosthesis]

Aseptic looseningis is one of the most frequent long-term complications after joint replacement, which limits the service lire of prosthesis. A lot of studies have been focused on macrophage, osteoblast, osteoclast and fibroblast in interface membranes around prostheses recently. Aseptic loosening of orthopedic implants used in joint replacement results from bone loss that occurs through the resorptive activity of inflammatory cells activated by the presence of wear particles. Apoptosis has been observed in the periprosthetic site and it has been interpreted as a sign of resolution of inflammation suggesting that apoptosis-related events are indeed associated with periprosthetic osteolysis,targeting the Apoptosis pathway may lead to novel therapeutic approaches for the treatment of aseptic prosthesis loosening. In this thesis,the relationship between wear debris-induced apoptosis and aseptic loosening of prostheses are expounded in detail.