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Updated: May 4, 2026

Formation of Dispersible Taohong Siwu Tablets
Published on: February 3, 2023
[Preparation of Shuxiong pulsatile controlled-release dropping pill]
Hui Chen1, Yan-Zhong Chen2, Qing-Chun Xie2
1Institute of Material Medica/Guangdong Provinical Key Laboratory of Advanced Drug Delivery, Guangdong Pharmaceutical University, Guangzhou 510006, China. chenhuicherry1987@163.com
Objective:
To prepare Shuxiong pulsatile controlled-release dropping pill and study the influencing factors in vitro.
Methods:
Dropping pills with suitable size (10 - 15 mg) were coated with swelling layer containing croscarmellose sodium and controlled-release layer containing ethylcellulos aqueous dispersion respectively to prepare Shuxiong pulsatile controlled-release dropping pill. The effects of the materials of swelling layer, the weight of swelling layer and controlled-release layer on the release of drugs were investigated to optimize the process technology and validate formula.
Results:
The release behavior was influenced strikingly by the types and weight of coating layer. The optimal formula was as follows: Shuxiong pulsatile controlled-release dropping pills were prepared using croscarmellose sodium as inner layer with 15% (weight) coating level and ethylcellulose aqueous dispersion (Surelease) as outer controlled-release layer with 7% (weight) coating level. The lag time of prepared pulsatile controlled-release dropping pills was about 4 h and accumulative release rate reached 80% within 4 h.
Conclusion:
The drug release of Shuxiong pulsatile controlled-release dropping pill is shown in pulsatile way in vitro.
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