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Myeloid Innate Signaling Pathway Regulation by MALT1 Paracaspase Activity
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MUC1: a novel metabolic master regulator.

Kamiya Mehla1, Pankaj K Singh2

  • 1The Eppley Institute for Research in Cancer and Allied Diseases, Fred & Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE 68198, USA.

Biochimica Et Biophysica Acta
|January 15, 2014
PubMed
Summary

MUC1 protein, overexpressed in epithelial cancers, regulates cell metabolism and survival by controlling gene expression and enzyme activity. This review details MUC1's novel metabolic roles in cancer progression.

Keywords:
Cancer metabolismGlycolysisMUC1Nutrient stress and carbon flux

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Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Metabolism

Background:

  • Mucin 1 (MUC1) is a type I transmembrane protein.
  • MUC1 is overexpressed and aberrantly glycosylated in epithelial cancers.
  • Loss of apical-basal polarity in cancer leads to aberrant MUC1 signaling.

Purpose of the Study:

  • To provide a comprehensive review of the recent literature on the novel metabolic functions of MUC1.
  • To highlight MUC1's role in regulating metabolite flux at multiple levels in cancer.

Main Methods:

  • Literature review of recent studies on MUC1 and cancer metabolism.
  • Analysis of MUC1's functions as a transcriptional co-activator.
  • Examination of MUC1's regulation of receptor tyrosine kinase signaling.
  • Investigation of MUC1's direct interactions with metabolic enzymes and transcription factors.
  • Assessment of MUC1's modulation of cellular processes like autophagy and reactive oxygen species.

Main Results:

  • MUC1 directly regulates the expression of metabolic genes.
  • MUC1 facilitates the production of biosynthetic intermediates for cell growth by regulating receptor tyrosine kinase signaling.
  • MUC1 modulates the activity and stability of key metabolic enzymes and transcription factors.
  • MUC1 enhances cancer cell survival under hypoxic and nutrient-deprived conditions by modulating autophagy, reactive oxygen species, and metabolite flux.

Conclusions:

  • MUC1 plays a critical role in regulating cancer cell metabolism and survival.
  • Aberrant MUC1 signaling in cancer contributes to metabolic reprogramming.
  • MUC1 represents a potential therapeutic target for modulating cancer metabolism.