Related Experiment Video

Updated: May 4, 2026

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis
11:44

Analysis of Combinatorial miRNA Treatments to Regulate Cell Cycle and Angiogenesis

Published on: March 30, 2019

6.8K

Review of MicroRNA Deregulation in Oral Cancer. Part I

Antonia Kolokythas1, Michael Miloro2, Xiaofeng Zhou3

  • 1Department of Oral and Maxillofacial Surgery, University of Illinois at Chicago USA. ; Center of Molecular Biology and Oral Diseases, College of Dentistry, University of Illinois at Chicago USA. ; Cancer Center, University of Illinois at Chicago USA.

Journal of Oral & Maxillofacial Research
|January 15, 2014
PubMed
Abstract

Insights

MicroRNA deregulation is evident in oral cancers, with specific microRNAs identified and their target genes validated. This research enhances understanding of oral cancer progression and potential targeted therapies.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Oral cancer is a significant global health concern, ranking as the sixth most common malignancy worldwide.
  • Tumor development involves the interplay of tumor suppressor gene inactivation and proto-oncogene activation, regulated partly by microRNAs.
  • MicroRNAs are crucial in controlling cellular functions like proliferation, differentiation, and apoptosis, and their aberrant expression is linked to various cancers.

Purpose of the Study:

  • To review existing literature on microRNA deregulation in head and neck/oral cavity cancers.
  • To synthesize current knowledge regarding microRNA alterations in oral cancer development and progression.

Main Methods:

  • A comprehensive literature review was conducted from 2000 to 2011.
  • Databases searched included PubMed, Medline, Scholar Google, and Scopus.
  • Keywords focused on microRNA and oral cancer, squamous cell carcinoma, and deregulation. Full-length English articles were included.

Main Results:

  • Multiple studies identified microRNA alterations in head and neck/oral cavity cancers.
  • Significant progress has been made in pinpointing specific deregulated microRNAs in oral cancers.
  • Several microRNAs have been functionally validated, with their target genes identified.

Conclusions:

  • MicroRNA deregulation in oral cancer offers insights into disease progression and treatment response.
  • Understanding these microRNA alterations may aid in developing novel targeted therapies for oral cancer.
Keywords:
head and neck cancerhead and neck neoplasmsmicroRNAoral canceroral neoplasmsreview.

More Related Videos

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method09:06

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

555
An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells09:45

An In Vitro Protocol for Evaluating MicroRNA Levels, Functions, and Associated Target Genes in Tumor Cells

Published on: May 21, 2019

8.1K

Related Concept Videos

MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
3.0K
MicroRNAs01:22

MicroRNAs

MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
21.1K
MicroRNAs01:22

MicroRNAs

9.8K
Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.0K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.6K
Mechanisms of Retrovirus-induced Cancers01:51

Mechanisms of Retrovirus-induced Cancers

Retroviruses are RNA viruses that have been shown to cause cancers in diverse species, including chickens, mice, cats, and monkeys. The RNA genomes of these viruses are first reverse-transcribed into single and then double-stranded DNA (dsDNA) copies. This dsDNA called proviral DNA then integrates into the host genome. Subsequently, the host cell transcribes the proviral DNA in concert with the chromosomal DNA. This leads to the production of viral RNA and proteins that assemble at the host...
5.2K