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Organic nitrates for osteoporosis: an update
Celeste J Hamilton1, Lauren S Reid2, Sophie A Jamal3
1Multidisciplinary Osteoporosis Research Program, Women's College Hospital, University of Toronto , Toronto, Ontario, Canada ; Department of Exercise Sciences, University of Toronto, Women's College Research Institute , Toronto, Ontario, Canada.
Bonekey Reports
|January 15, 2014
Summary
Nitric oxide (NO) shows promise for treating osteoporotic fractures, especially at cortical bone sites. This review explores NO
Area of Science:
- Bone biology and osteoporosis research.
- Pharmacology of nitric oxide.
- Geriatric medicine and fracture prevention.
Background:
- Osteoporotic fractures are a growing global health concern, particularly in aging populations.
- Current treatments are limited in efficacy at cortical bone sites and by cost, side effects, and availability.
- Nitric oxide (NO) presents a potential therapeutic avenue due to its accessibility, low cost, and minimal side effects.
Purpose of the Study:
- To review the role of nitric oxide (NO) in bone cell function.
- To evaluate the effects of organic nitrates on bone health.
- To assess NO's potential for treating osteoporotic fractures, especially at cortical sites.
Main Methods:
- In vitro studies on bone cell function.
- In vivo animal studies.
- Observational, case-control, and randomized controlled trials on organic nitrates.
Main Results:
- NO plays a significant role in bone cell function.
- Organic nitrates demonstrate effects on bone turnover, geometry, and strength.
- Evidence suggests NO influences cortical bone, a common fracture site.
Conclusions:
- Nitric oxide (NO) is a promising, cost-effective agent for managing osteoporotic fractures.
- Further research into NO-based therapies could address limitations of current treatments.
- NO's potential impact on cortical bone warrants continued investigation for fracture prevention.
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