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Related Concept Videos

Hormones and Bone Tissue01:17

Hormones and Bone Tissue

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The endocrine system produces and secretes hormones, which interact with the skeletal system. These hormones control bone growth, maintain bone once it is formed, and remodel it.
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Bone Remodeling01:40

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Bone remodeling is a continuous and balanced process of bone resorption by osteoclasts and bone formation by osteoblasts. In adults, it helps maintain bone mass and calcium homeostasis. While mechanical stress can stimulate turnover as part of the normal maintenance and reparative process, several hormones also regulate bone remodeling.
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Essential Minerals for Bone Health01:31

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The minerals contained in all of the food we consume are essential for our organ systems. However, certain essential minerals, such as calcium, phosphorus, magnesium, manganese, and fluoride, largely affect bone health.
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The Bone Matrix01:18

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Bone contains a relatively small number of cells entrenched in a matrix of collagen fibers that provide an adherent surface for inorganic salt crystals. Both components of the matrix, organic and inorganic, contribute to the unusual properties of bone. Without collagen, bones would be brittle and shatter easily. Without mineral crystals, bones would flex and provide little support. This can be observed by an experiment: when the minerals of a bone are dissolved by soaking the bone in...
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Osteoclasts in Bone Remodeling01:31

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Osteoclasts are cells responsible for bone resorption and remodeling. They originate from hematopoietic progenitor cells present in the bone marrow. Numerous progenitor cells fuse to form multinucleated cells, each with 10-20 nuclei. A single osteoclast has a diameter of 150 to 200 µM. These cells have ruffled borders that break down the underlying bone tissue and release minerals such as calcium into the blood in bone resorption. Osteoclasts cling to bones with their ruffled edges during...
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Bone Disorders01:29

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Aging and its effect on bone remodeling is the most common cause of bone disorders. In young and healthy people, bone deposition and resorption happen at an equal rate to maintain optimal bone health.
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Protein/amino-acid modulation of bone cell function.

Robert MacDonell1, Mark W Hamrick2, Carlos M Isales3

  • 1Institute for Regenerative and Reparative Medicine, Medical College of Georgia, Augusta University , Augusta, GA, USA.

Bonekey Reports
|February 3, 2017
PubMed
Summary
This summary is machine-generated.

Dietary protein significantly impacts bone health, influencing bone cells and overall bone metabolism. Understanding these complex nutrient effects is crucial for managing age-associated bone loss.

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Area of Science:

  • Nutritional Science
  • Bone Biology
  • Cellular Metabolism

Background:

  • Traditionally, nutrients were viewed solely as energy sources for cellular activity.
  • Emerging evidence reveals complex nutrient interactions with bone cells (stem cells, osteoblasts, osteoclasts).
  • Nutrient intake influences bone at both organ and cellular levels, affecting bone formation and breakdown.

Purpose of the Study:

  • To review the intricate effects of nutrients, particularly dietary protein, on bone cell function and bone metabolism.
  • To explore the mechanisms by which nutrients impact cellular energetics and hormonal regulation related to bone.
  • To highlight the translational implications of dietary protein intake for age-associated bone loss.

Main Methods:

  • Literature review focusing on nutrient effects on bone cells.
  • Analysis of direct and indirect nutrient impacts on cellular energetics.
  • Examination of nutrient-related hormonal modulation of bone activity.

Main Results:

  • Nutrient effects on bone cells are complex; some promote formation, others inhibit it or increase breakdown.
  • Nutrient intake can suppress bone resorption and modulate the calcium/vitamin D/parathyroid hormone axis.
  • Individual components within nutrient classes, like amino acids in protein, can have distinct effects on bone formation.

Conclusions:

  • Dietary protein's role in bone health is multifaceted, impacting cellular processes and hormonal pathways.
  • Optimal dietary protein intake may be critical for mitigating age-associated bone loss.
  • Further research into specific nutrient components and their effects on bone is warranted.