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Updated: May 4, 2026

Human Dupuytren's Ex Vivo Culture for the Study of Myofibroblasts and Extracellular Matrix Interactions
Published on: April 18, 2015
[Dupuytren's disease]
Emmanuel Masmejean1, Daniel Tordjman2
1Unité de chirurgie de la main et des nerfs péeriphériques, hôpital européen Georges-Pompidou, AP-HP, Paris-Descartes, Sorbonne Paris Cité, Paris, France. emmanuel.masmejean@egp.aphp.fr
Insights
Dupuytren's disease is a hand condition causing finger contractures due to palmar fascia fibrosis. Current treatments include needle fasciotomy, surgery, or collagenase injections, but recurrence is common.
Area of Science:
- Hand surgery
- Fibrotic disorders
- Dermatology
Context:
- Dupuytren's disease involves retractile fibrosis of the palmar fascia, leading to finger contractures.
- Etiology is unclear, but genetics and diabetes are identified risk factors.
- Affects middle-aged Caucasian males, with ectopic manifestations like Ledderhose's disease.
Purpose:
- To review the clinical presentation, risk factors, and treatment strategies for Dupuytren's disease.
- To discuss the efficacy of various interventions, including needle fasciotomy, surgery, and enzymatic fasciotomy.
- To highlight the challenge of recurrence and palliative options.
Summary:
- Characteristic signs include palmar nodules and cords causing contractures; treatment is indicated when hands cannot lie flat.
- Therapeutic options range from needle fasciotomy for palmar forms to surgical fasciectomy for digitopalmar involvement.
- Emerging enzymatic fasciotomy with collagenase shows promise, though recurrence remains frequent, necessitating options like dermofasciectomy or arthrodesis.
Impact:
- Provides a comprehensive overview of Dupuytren's disease management.
- Informs clinical decision-making regarding the choice of treatment based on disease severity.
- Highlights the ongoing need for effective treatments to manage recurrence and improve patient outcomes.
Abstract:
Dupuytren's disease, first described in 1831 by G. Dupuytren, is a mysterious retractile fibrosis of the palmodigital aponeurosis. Its etiology remains unclear despite various risk factors identified including genetics factors. Most patients are middle age males and have Caucasian's origin (northern Europe). Among risk factors, diabetes is the most frequent associated disease. Characteristic clinical signs are the palmar nodules, ombilications and cords causing finger contractures. There is various clinical features with also ectopic signs: Ledderhose's disease, Lapeyronie's disease and dorsal pads. There is no conservative treatment. The treatment is justified when the patient can't put his hand flat on the table (Hueston's test). Therapeutic strategy depends on the extent and level of retractions. Needle fasciotomy is preferred for palmar forms. Surgery (fasciectomy) is the standard procedure for digitopalmar forms because of complexity of band's anatomy and its proximity with the neurovascular bundle. Enzymatic fasciotomy using collagenase injections have been recently developped. Published results are hopeful and assessment in Europe is underway. Anyhow the used technique, recurrence is frequent and can be treated by dermofasciectomy. Palliative surgery, as arthrodesis, can be necessary in case of recurrency.
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