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Updated: May 4, 2026

Evaluation of the Interplay Between the Complement Protein C1q and Hyaluronic Acid in Promoting Cell Adhesion
Published on: June 15, 2019
Anti-complementary constituents of Houttuynia cordata and their targets in complement activation cascade
Yun Jiang1, Yan Lu, Yun-Yi Zhang
1a Department of Pharmacognosy , School of Pharmacy, Fudan University , Shanghai 201203 , P.R. China.
Abstract:
Activity-guided fractionation for complement inhibitors led to the isolation of 23 known compounds from Houttuynia cordata Thunb. Seven flavonoids, two alkaloids, one coumarin and two phenols showed anti-complementary activity. Preliminary inhibitory mechanism of four flavonoids, including quercitrin, afzelin, isoquercitrin and quercetin in the complement activation cascade were examined for the first time. The results indicated that the target components of flavonols are different from those of flavonosides, and the glycoside moieties may be necessary to block C3 and C4 components.
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