Related Experiment Video
Updated: May 4, 2026

Endoscopic Endonasal Trans-sphenoidal Approach: Minimally Invasive Surgery for Pituitary Adenomas
Published on: January 17, 2018
Papilledema as the initial presentation of Castleman disease
Guohong Tian1, Yun Jing, Hanqiu Jiang
1Department of Ophthalmology (GT), Eye and ENT Hospital, Fudan University, Shanghai, China; and Departments of Neurology (YJ, HJ, XZ) and Hematology (JW), Beijing Tongren Hospital, Capital Medical University, Beijing, China.
Abstract:
Castleman disease is a rare lymphoproliferative disorder that has many presentations ranging from unifocal or multifocal mass lesions to a monoclonal gammopathy. It has features that may overlap with osteosclerotic myeloma or POEMS (polyneuropathy, organomegaly, endocrinopathy, M protein, skin changes) syndrome. We report a patient with papilledema, enlarged lymph nodes, and monoclonal IgG, who subsequently developed a polyneuropathy. Biopsy of enlarged mediastinal lymph nodes confirmed the diagnosis of Castleman disease.
Related Concept Videos
Cerebral Edema ll: Pathophysiology
Increased Intracranial Pressure l: Introduction
Cerebral Edema l: Introduction
Increased Intracranial Pressure ll: Pathophysiology
Cirrhosis I: Introduction
Brain Abscess l: Introduction

