Related Experiment Video
Updated: May 4, 2026
05:19
Magnetic Resonance Imaging Assessment of Carcinogen-induced Murine Bladder Tumors
Published on: March 29, 2019
9.8K
Urinary tumor markers could predict survival in bladder carcinoma
Ragaa H M Salama1, Tahia H Selem2, Mohammed El-Gammal3
1Biochemistry Department, Faculty of Medicine, Assiut University, Assiut, Egypt ; Department of Medical Biochemistry, Faculty of Medicine, Assiut University, Assiut, Egypt.
Indian Journal of Clinical Biochemistry : IJCB
|January 16, 2014
Summary
Early bladder cancer detection is improved using urinary tumor markers like NMP22 and E-cadherin. These markers aid in identifying disease progression and predicting recurrence in at-risk individuals.
Area of Science:
- Urology
- Oncology
- Biochemistry
Background:
- Early diagnosis of bladder cancer is crucial for effective treatment outcomes.
- Urinary tumor markers are being investigated for their potential in non-invasive bladder cancer detection.
Purpose of the Study:
- To evaluate nuclear matrix protein 22 (NMP 22), soluble E-cadherin, cathepsin-D, and total protein as biomarkers for bladder cancer.
- To correlate these markers with clinico-pathological features and predict tumor progression and recurrence.
Main Methods:
- Assessed urinary levels of NMP 22, E-cadherin, cathepsin-D, and total protein in 65 bladder cancer patients, 14 benign urinary disease patients, and 11 healthy volunteers.
- Analyzed marker correlations with tumor stage, grade, size, lymph node metastasis, and bilharzial infestation.
- Followed 40 patients post-surgery to assess disease progression.
Main Results:
- Significantly elevated levels of NMP22, E-cadherin, cathepsin-D, and total protein were found in bladder cancer patients compared to control groups.
- NMP 22 and E-cadherin demonstrated high sensitivity (84.4%, 76.9%), while total protein showed high specificity (77.4%).
- Elevated pretreatment levels of NMP22, E-cadherin, and total protein significantly correlated with bladder cancer recurrence.
Conclusions:
- Urinary NMP 22, E-cadherin, and total protein show promise for early bladder cancer detection and recurrence prediction.
- Combining multiple tumor markers offers greater utility than single marker assessment for bladder cancer management.
