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Synthesis, Characterization, and Application of Superparamagnetic Iron Oxide Nanoprobes for Extrapulmonary Tuberculosis Detection
Published on: February 16, 2020
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Hyperferritinemia in pulmonary tuberculosis.
Benedicta D'Souza1, Sulekha Sinha1, Poornima Manjrekar1
1Dept. of Biochemistry, Centre for Basic Sciences, Manipal University, Kasturba Medical College, Bejai, Mangalore, 575004 India.
Indian Journal of Clinical Biochemistry : IJCB
|January 16, 2014
Summary
High ferritin levels are linked to tuberculosis. In a case study, an individual with multidrug-resistant tuberculosis and diabetes exhibited extremely high ferritin, suggesting iron
Area of Science:
- Medical research
- Infectious diseases
- Hematology
Background:
- High ferritin levels are associated with various infectious and non-infectious conditions.
- Tuberculosis (TB) is one such infectious disease where elevated ferritin has been observed.
- Understanding the role of iron metabolism in TB is crucial for patient management.
Observation:
- A 41-year-old male presented with a persistent cough and expectoration.
- The patient was diagnosed with multidrug-resistant tuberculosis (MDRTB) and type 2 diabetes mellitus.
- Initial laboratory results revealed significantly elevated iron and ferritin levels, with low total iron-binding capacity.
Findings:
- The patient's ferritin level was exceptionally high at 92,945 ng/ml.
- Iron levels were 280 μg/dl, and total iron-binding capacity (TIBC) was 61 μg/dl.
- These findings suggest a strong correlation between iron availability and the survival of Mycobacterium tuberculosis.
Implications:
- Extremely high ferritin levels in TB patients may indicate a critical role for iron in pathogen proliferation.
- This case highlights the potential link between iron metabolism dysregulation and the severity of multidrug-resistant tuberculosis.
- Further research is warranted to explore iron chelation or management strategies in MDRTB treatment.
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