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Related Concept Videos

Coronary Artery Disease I: Introduction01:30

Coronary Artery Disease I: Introduction

Coronary Artery Disease (CAD): An Overview with Scientific InsightsCoronary Artery Disease (CAD), often referred to as C-A-D, is a prevalent blood vessel disorder classified under the broader category of atherosclerosis. Atherosclerosis is a pathological process characterized by the hardening and narrowing of arteries due to the accumulation of atherosclerotic plaques. These plaques are composed of cholesterol, fatty substances, inflammatory cells, calcium, and fibrin, reducing blood flow to...
Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT01:25

Imaging Studies for Cardiovascular System VI: Calcium -Scoring CT

Calcium-Scoring CT ScanA calcium-scoring CT scan, also known as coronary artery calcium (CAC) scan, detects calcium deposits in the coronary arteries. This test assesses the risk of coronary artery disease (CAD), which can lead to cardiovascular events such as angina, heart failure, and sudden cardiac arrest.A calcium-scoring CT scan is generally recommended for individuals at intermediate risk of CAD without symptoms. It includes:Men aged 40-75 and women aged 50-75: Especially those with a...
Coronary Artery Disease IV: Preventive Measures01:26

Coronary Artery Disease IV: Preventive Measures

Effective preventive measures for coronary artery disease (CAD) focus on controlling modifiable risk factors, including cholesterol abnormalities and lifestyle changes.Cholesterol ManagementFirst, the Mediterranean diet and the American Heart Association advocate for maintaining low-density lipoprotein (LDL) cholesterol levels below 100 mg/dL, with a more stringent recommendation of below 70 mg/dL for individuals at high risk. LDL cholesterol, often termed "bad cholesterol," can lead to the...
Atherosclerosis III: Management01:26

Atherosclerosis III: Management

Management of atherosclerosis involves an integrated strategy encompassing pharmacological treatment, surgical interventions, lifestyle changes, and nutrition therapy to address the multifactorial nature of the disease.Pharmacological TherapyA cornerstone of atherosclerosis management is the use of pharmacological agents. Statins, such as atorvastatin, are pivotal in inhibiting HMG-CoA reductase, an enzyme that catalyzes an initial step in cholesterol synthesis in the liver. This reduction in...
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
Atherosclerosis I: Introduction01:30

Atherosclerosis I: Introduction

Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...

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Related Experiment Video

Updated: May 29, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Elevated Oxidized LDL Level is Associated with Systematic Coronary Risk Evaluation (SCORE2) High-Risk Prediction

Asim Orem1, Büşra Bilgin1, Seda Altuntas2

  • 1Department of Medical Biochemistry, Faculty of Medicine, Karadeniz Technical University, 61080 Trabzon, Turkey.

Indian Journal of Clinical Biochemistry : IJCB
|May 28, 2026
PubMed
Summary
This summary is machine-generated.

Oxidized LDL (ox-LDL) may improve cardiovascular risk prediction. This study found ox-LDL levels correlate strongly with the SCORE2 model, suggesting its potential as a marker for identifying high-risk individuals needing preventive action.

Keywords:
Oxidative stress parametersOxidized LDLSCORE2

Related Experiment Videos

Last Updated: May 29, 2026

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
07:29

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein

Published on: October 12, 2017

Area of Science:

  • Cardiovascular research
  • Biomarkers
  • Atherosclerosis

Background:

  • Cardiovascular disease (CVD) risk estimation is crucial for preventive strategies, particularly for high-risk individuals, often assessed using the SCORE2 model.
  • Oxidative stress is implicated in atherosclerosis progression and may influence CVD risk.
  • Identifying novel biomarkers can enhance the accuracy of existing risk prediction models.

Purpose of the Study:

  • To investigate the relationship between oxidative stress parameters and the SCORE2 cardiovascular risk prediction model.
  • To determine if specific oxidative stress markers can improve high-risk CVD prediction.
  • To evaluate oxidized low-density lipoprotein (ox-LDL) as a potential risk marker.

Main Methods:

  • Measured oxidative stress markers (ox-LDL, MDA, OSI, 3-NT, 8-OHdG, total thiols) and inflammatory factors (TNF-α, IL-6) in study groups.
  • Included patients with and without coronary artery disease (CAD).
  • Utilized Receiver Operating Characteristic (ROC) analysis and correlation analysis with the SCORE2 model.

Main Results:

  • Significant differences in oxidative stress parameters were observed among study groups.
  • Oxidized LDL (ox-LDL) showed high diagnostic value (AUC: 0.998) and was associated with increased odds of high risk (OR: 1.68).
  • Ox-LDL levels increased progressively across SCORE2 risk strata and demonstrated the strongest correlation with SCORE2 (r=0.48).

Conclusions:

  • Circulating ox-LDL levels show a strong association with the SCORE2 cardiovascular risk score.
  • Ox-LDL may serve as a valuable candidate biomarker for enhancing the accuracy of high-risk CVD prediction.
  • Further research could integrate ox-LDL into clinical risk assessment tools for improved preventive care.