Elevated Oxidized LDL Level is Associated with Systematic Coronary Risk Evaluation (SCORE2) High-Risk Prediction...

Area of Science:

• Cardiovascular research
• Biomarkers
• Atherosclerosis

Background:

• Cardiovascular disease (CVD) risk estimation is crucial for preventive strategies, particularly for high-risk individuals, often assessed using the SCORE2 model.
• Oxidative stress is implicated in atherosclerosis progression and may influence CVD risk.
• Identifying novel biomarkers can enhance the accuracy of existing risk prediction models.

Purpose of the Study:

• To investigate the relationship between oxidative stress parameters and the SCORE2 cardiovascular risk prediction model.
• To determine if specific oxidative stress markers can improve high-risk CVD prediction.
• To evaluate oxidized low-density lipoprotein (ox-LDL) as a potential risk marker.

Main Methods:

• Measured oxidative stress markers (ox-LDL, MDA, OSI, 3-NT, 8-OHdG, total thiols) and inflammatory factors (TNF-α, IL-6) in study groups.
• Included patients with and without coronary artery disease (CAD).
• Utilized Receiver Operating Characteristic (ROC) analysis and correlation analysis with the SCORE2 model.

Main Results:

• Significant differences in oxidative stress parameters were observed among study groups.
• Oxidized LDL (ox-LDL) showed high diagnostic value (AUC: 0.998) and was associated with increased odds of high risk (OR: 1.68).
• Ox-LDL levels increased progressively across SCORE2 risk strata and demonstrated the strongest correlation with SCORE2 (r=0.48).

Conclusions:

• Circulating ox-LDL levels show a strong association with the SCORE2 cardiovascular risk score.
• Ox-LDL may serve as a valuable candidate biomarker for enhancing the accuracy of high-risk CVD prediction.
• Further research could integrate ox-LDL into clinical risk assessment tools for improved preventive care.