Related Experiment Video
Updated: May 4, 2026
09:06
Live-3D-Cell Immunocytochemistry Assays of Pediatric Diffuse Midline Glioma
Published on: November 11, 2021
2.2K
Wilms' tumor: single centre retrospective study from South India
B Guruprasad1, B Rohan1, S Kavitha2
1Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Post graduate hostel Room number 108, Dr M H Marigowda road, Bangalore, 560029 India.
Indian Journal of Surgical Oncology
|January 16, 2014
Summary
This study analyzed Wilms tumor outcomes in India using the National Wilms' Tumor Study Group (NWTS) IV protocol. Favorable histology significantly impacts survival, with 5-year event-free survival at 83.3% and overall survival at 85.2%.
Area of Science:
- Pediatric Oncology
- Nephrology
- Cancer Research
Background:
- Wilms' tumor is the most common kidney cancer in children.
- Prognosis has improved significantly, but Indian data is limited.
- Multimodal treatment (surgery, radiotherapy, chemotherapy) is standard.
Purpose of the Study:
- To analyze the clinicopathologic profile and outcomes of Wilms' tumor in India.
- To evaluate treatment adherence to the NWTS IV protocol.
- To identify factors influencing survival rates.
Main Methods:
- Retrospective analysis of 61 patients treated from 2003-2010.
- Treatment followed NWTS IV protocol guidelines.
- Outcomes assessed for overall survival and event-free survival, correlated with clinicopathologic factors.
Main Results:
- Favorable histology observed in 80.3% of cases; unfavorable in 19.7%.
- Estimated 5-year event-free survival was 83.3%; overall survival was 85.2%.
- Tumor histology emerged as the most critical factor predicting survival.
Conclusions:
- Tumor histology is crucial for Wilms' tumor prognosis.
- Late presentation in India poses surgical challenges.
- A multidisciplinary approach can achieve survival rates comparable to NWTS findings.
