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Epigenetic changes in carcinogenesis of gallbladder.
Mallika Tewari1, Amit Agarwal1, R R Mishra2
1Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, 221 005 U.P. India.
Indian Journal of Surgical Oncology
|January 16, 2014
Summary
Gallbladder cancer (GBC) is a lethal malignancy, particularly in northern India. This review summarizes current knowledge on the epigenetic changes involved in gallbladder carcinogenesis.
Area of Science:
- Oncology
- Molecular Biology
- Genetics
Background:
- Gallbladder cancer (GBC) is a lethal malignancy with high incidence in specific global regions, notably northern India.
- While genetic mutations are studied, the role of epigenetic alterations in GBC development is under-researched.
- The etiology of GBC remains largely unknown, necessitating further investigation into contributing factors.
Purpose of the Study:
- To review and summarize the current understanding of epigenetic alterations in gallbladder cancer.
- To highlight the potential role of epigenetics in gallbladder carcinogenesis.
- To identify gaps in knowledge regarding GBC epigenetics.
Main Methods:
- Literature review of studies on gallbladder cancer.
- Analysis of reported genetic and epigenetic changes in GBC.
- Synthesis of existing data on epigenetic modifications in gallbladder carcinogenesis.
Main Results:
- Epigenetic changes, including DNA methylation and histone modifications, are implicated in GBC.
- Specific epigenetic alterations may contribute to the development and progression of gallbladder cancer.
- Data on epigenetic modifications in GBC is scarce compared to genetic aberrations.
Conclusions:
- Epigenetic alterations represent a significant area for future research in GBC etiology and treatment.
- Understanding epigenetic changes could reveal novel therapeutic targets for gallbladder cancer.
- Further studies are needed to elucidate the precise mechanisms of epigenetic involvement in GBC.
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