Related Experiment Video

Updated: May 4, 2026

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS
14:15

Preparation of Myeloid Derived Suppressor Cells MDSC from Naive and Pancreatic Tumor-bearing Mice using Flow Cytometry and Automated Magnetic Activated Cell Sorting AutoMACS

Published on: June 18, 2012

25.7K

Myeloid-derived suppressor cells: Cellular missiles to target tumors

Dinesh Chandra1, Claudia Gravekamp1

  • 1Albert Einstein College of Medicine; Department of Microbiology and Immunology; Bronx, NY USA.

Oncoimmunology
|January 16, 2014
PubMed

Insights

Myeloid-derived suppressor cells (MDSCs) deliver targeted cancer therapy. This novel approach effectively targets primary tumors and metastases, inhibiting growth and reducing spread in pancreatic cancer models.

Area of Science:

  • Oncology
  • Immunotherapy
  • Cancer Metastasis

Background:

  • Conventional cancer treatments struggle to eliminate metastatic disease due to inefficient drug delivery.
  • Metastasis remains a significant challenge in treating pancreatic cancer and other malignancies.

Approach:

  • Utilized attenuated *Listeria monocytogenes* coupled with a radioisotope as a payload.
  • Engineered myeloid-derived suppressor cells (MDSCs) to act as targeted delivery vehicles.
  • Administered MDSC-delivered therapy to mice with pancreatic cancer.

Key Points:

  • MDSCs selectively delivered the therapeutic payload to both primary and metastatic tumor sites.
  • The novel immunotherapeutic approach demonstrated robust inhibition of primary tumor growth.
  • A significant reduction in the number of metastases was observed.

Conclusions:

  • Myeloid-derived suppressor cells (MDSCs) show promise as a targeted delivery system for cancer therapy.
  • This strategy offers a potential new avenue for combating metastatic cancer, particularly pancreatic cancer.
  • Further research into MDSC-mediated drug delivery could overcome limitations of conventional treatments.
Keywords:
Cancer vaccineListeriaMDSCTumor microenvironmenttargeted therapy

More Related Videos

Isolation and Characterization of Neutrophils with Anti-Tumor Properties10:15

Isolation and Characterization of Neutrophils with Anti-Tumor Properties

Published on: June 19, 2015

24.5K
Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model08:06

Experimental Metastasis and CTL Adoptive Transfer Immunotherapy Mouse Model

Published on: November 26, 2010

19.1K

Related Concept Videos

Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
7.0K
Differentiation of Common Myeloid Progenitor Cells01:15

Differentiation of Common Myeloid Progenitor Cells

Common myeloid progenitors (CMPs) are oligopotent cells that can differentiate into granulocytes and macrophages. Granulocytes and macrophages are essential for protecting the body against bacterial, viral, or fungal infections. They migrate from the bone marrow into the circulating blood to reach specific tissue sites where they differentiate and help in immune surveillance. However, they survive only for a few days and must be continuously made available to the organism to maintain a robust...
3.1K
Cancer Stem Cells and Tumor Maintenance02:40

Cancer Stem Cells and Tumor Maintenance

Early diagnosis and treatment can often cure cancer. However, even with treatment, residual cells called cancer stem cells (CSC) might remain, often causing tumor recurrence. These cancer stem cells possess the potential for self-renewal and multi-lineage differentiation and are often responsible for the therapeutic resistance displayed in most cancers.
Cancer stem cells are thought to originate from tissue-specific normal stem cells or progenitor cells. The normal stem cells usually reside in...
4.3K
Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...
7.0K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K