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Epistaxis01:30

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Epistaxis, or nosebleeds, occurs when small, swollen blood vessels in the nasal mucous membrane rupture. Typically, the anterior septum is the primary site of occurrence.
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Collecting And Measuring Wound Exudate Biochemical Mediators In Surgical Wounds
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Can clonidine as a pre-anaesthetic drug decrease bleeding during rhinoplasty surgery?

Ali Ghazipour1, Khashayar Ahmadi2, Mozaffar Sarafraz1

  • 1ENT Department, Ahvaz Jondi Shapour Medical University, Ahwaz, Iran.

Indian Journal of Otolaryngology and Head and Neck Surgery : Official Publication of the Association of Otolaryngologists of India
|January 16, 2014
PubMed
Summary
This summary is machine-generated.

Oral Clonidine effectively reduces bleeding during rhinoplasty surgery. This study found significantly less blood loss in patients receiving Clonidine compared to placebo, highlighting its potential as a pre-anesthetic agent.

Keywords:
BleedingClonidineRhinoplasty

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Area of Science:

  • Anesthesiology
  • Pharmacology

Background:

  • Clonidine, an alpha-2 adrenergic agonist, is known for its antihypertensive, anxiolytic, and analgesic properties.
  • Previous studies suggest Clonidine's efficacy in reducing bleeding during various surgical procedures, including neurosurgery, orthopedics, and endoscopic surgeries.

Purpose of the Study:

  • To investigate the effect of oral Clonidine as a pre-anesthetic medication on blood loss during rhinoplasty surgery.

Main Methods:

  • A double-blinded, placebo-controlled clinical trial involving 80 patients undergoing rhinoplasty.
  • Patients were randomized to receive either 5 µg/Kg of oral Clonidine or a placebo pre-operatively.
  • Blood loss was quantified post-surgery by counting bloody standard gauzes, with patients categorized into four groups based on the amount of bleeding.

Main Results:

  • The group receiving oral Clonidine exhibited a statistically significant reduction in bleeding compared to the placebo group (P < 0.05).
  • Fewer patients in the Clonidine group fell into the higher bleeding categories (groups 3 and 4) compared to the placebo group (1.8 ± 0.04 vs. 3.1 ± 0.05).

Conclusions:

  • Oral Clonidine administration as a pre-anesthetic agent effectively decreases intraoperative bleeding during rhinoplasty.
  • Clonidine represents a viable option for managing blood loss in patients undergoing nasal and sinus endoscopic surgeries.