Related Experiment Video
Updated: May 4, 2026
A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset Callithrix jacchus
Published on: February 27, 2018
Intratympanic dexamethasone on cochlear blood flow in Guinea pigs
Rayleigh Ping-Ying Chiang1, Ching-Ying Yeh2, Yuh-Chyun Chiang3
1Department of Otolaryngology Head and Neck Surgery, School of Medicine, Fu Jen Catholic University, Taipei, Taiwan ; Department of Otolaryngology Head and Neck Surgery, Shin Kong Wu Ho-Su Memorial Hospital, Taipei, Taiwan ; Sleep Technology Special Interest Group, Center of Innovation and Synergy for Intelligent Home Technology, National Taiwan University, No.95, Wen-Chang Road, Shih-Lin District, Taipei, Taiwan.
Unlabelled:
To determine the effect of intratympanically delivered dexamethasone on cochlear blood flow. 29 white Hartly guinea pigs were divided into 2 groups. By laser Doppler flowmeter, baseline data were recorded in the first 15-20 min, followed by 20 min' recording after applying dexamethasone or normal saline, with a record of flow every 5 min in 2 groups. Friedman Test was used to test the change of blood flow in these four timing. There were no significant changes of blood flow after injecting dexamethasone (p = .18 > .05) and normal saline (p = .93 > .05). The effects of dexamethasone on cochlear blood flow were variable and not significant. The following research would be designed under pathological conditions, such as cochlear ischemia, to show the possible mechanism of dexamethasone for specific inner ear disease.
Level Of Evidence:
3a (SR of case-control studies).
