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A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents
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A Simplified Model for Heterotopic Heart Valve Transplantation in Rodents

Published on: September 21, 2021

Valve replacement in children

E M Cornish, D G Human, M M de Moor

    The Thoracic and Cardiovascular Surgeon
    |June 1, 1987
    PubMed

    Insights

    The St. Jude prosthetic valve shows excellent performance in pediatric patients, with a 90% event-free survival rate up to 5 years. Anticoagulation was not essential for preventing complications in this study.

    Area of Science:

    • Cardiology
    • Pediatric Cardiac Surgery
    • Biomaterials Science

    Background:

    • Prosthetic heart valves are crucial for treating pediatric valvular heart disease.
    • Long-term durability and safety in pediatric populations remain critical considerations.
    • The St. Jude prosthetic valve is a mechanical option used in pediatric cardiac surgery.

    Purpose of the Study:

    • To evaluate the early and mid-term performance of the St. Jude prosthetic valve in pediatric patients.
    • To assess the incidence of complications and survival rates following valve replacement in children.
    • To compare the efficacy of different anticoagulation strategies in pediatric patients with prosthetic valves.

    Main Methods:

    • Retrospective review of 81 pediatric patients (aged 3-15 years) who underwent valve replacement.
    • Inclusion of mitral, aortic, and double valve replacements performed between February 1979 and August 1984.
    • Actuarial analysis to determine event-free survival and complication rates.

    Main Results:

    • Early mortality was 3.7% in the cohort.
    • Actuarial analysis demonstrated 90% event-free survival up to 5 years post-implantation.
    • No significant difference in complication rates was observed between patients receiving warfarin, aspirin, or no anticoagulation therapy.

    Conclusions:

    • The St. Jude prosthetic valve is well-suited for pediatric use, avoiding the early degeneration seen with heterograft valves.
    • Anticoagulation therapy was not essential for managing complications in this pediatric cohort.
    • The valve offers a durable and safe option for pediatric valvular heart disease treatment.

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