Recent applications of immunoperoxidase histochemistry in human neuro-oncology. An update

In this review, we describe some of the most commonly used antibodies and discuss their immunohistochemical applications to human neuro-oncology. We stress the importance of determining the spectrum of antibody immunoreactivity in a wide panel of normal, reactive, and neoplastic tissues, and the caution with which immunopositivity needs to be interpreted in atypical and aberrant cases. Whether the detection of a well-characterized, cell-type-specific marker in a tumor reflects histogenesis or solely differentiation potential is discussed in several examples.