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Related Experiment Video

Updated: May 4, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

Published on: November 26, 2018

MARCOing monocytes for elimination.

Lester Kobzik¹, Filip K Swirski

¹Department of Environmental Health, Harvard School of Public Health, Boston, MA 02114, USA.

Science Translational Medicine

|January 17, 2014

Summary

This summary is machine-generated.

Targeting inflammatory monocytes with MARCO receptor-binding microparticles offers a novel approach to mitigate inflammation and tissue damage. This strategy holds promise for reducing injury in various inflammatory conditions.

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Last Updated: May 4, 2026

Simultaneous Study of the Recruitment of Monocyte Subpopulations Under Flow In Vitro

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Published on: November 26, 2018

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Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes

Isolation and Intravenous Injection of Murine Bone Marrow Derived Monocytes

Published on: December 27, 2014

Area of Science:

Immunology
Biomedical Engineering

Background:

Inflammatory monocytes play a critical role in driving tissue injury during inflammatory responses.
Current therapeutic strategies often lack specificity, leading to off-target effects.

Purpose of the Study:

To investigate the efficacy of microparticles targeting the Macrophage Receptor with Collagen Domain (MARCO) for eliminating inflammatory monocytes.
To assess the potential of this approach in reducing inflammation and subsequent tissue injury.

Main Methods:

Development of microparticles engineered to bind specifically to the MARCO receptor present on inflammatory monocytes.
In vivo administration of these microparticles to models of inflammation.
Assessment of monocyte populations, inflammatory markers, and tissue damage.

Main Results:

Microparticles effectively targeted and depleted inflammatory monocytes expressing the MARCO receptor.
Significant reduction in key inflammatory mediators was observed.
Attenuated tissue injury was correlated with monocyte depletion.

Conclusions:

Targeted elimination of inflammatory monocytes via MARCO-binding microparticles is a viable therapeutic strategy.
This approach demonstrates potential for managing inflammatory diseases and preventing tissue damage.