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A sulfhydryl-rich IgM protein with multiple serological specificities
G Merlini1, O Zettervall, A Forsgren
1Department of Internal Medicine, Malmö General Hospital, University of Lund, Sweden.
Clinical and Experimental Immunology
|July 1, 1987
Summary
A unique IgM lambda protein from a patient with lymphocytic lymphoma binds to Salmonella typhi bacteria and acryl particles. This protein also shows high affinity for heavy metal ions, revealing abundant sulfhydryl groups in its Fab region.
Area of Science:
- Immunology
- Biochemistry
- Structural Biology
Background:
- Monoclonal antibodies, such as immunoglobulin M (IgM), are crucial tools in biological research and diagnostics.
- Lymphocytic lymphoma can be associated with the production of aberrant monoclonal proteins.
- Understanding the binding specificities and structural features of monoclonal antibodies provides insights into molecular interactions.