Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Infrared (IR) Spectroscopy: Overview01:09

Infrared (IR) Spectroscopy: Overview

6.8K
When electromagnetic radiation passes through a material, atoms or molecules transition from a lower to a higher energy state by absorbing radiation corresponding to the energy difference between the two states. The absorption of infrared (IR) radiation causes transitions between vibrational energy levels in a molecule. Therefore, IR spectroscopy is a useful analytical tool for determining the molecular structure of molecules.
Different compounds display unique properties due to their...
6.8K
IR Spectrometers01:25

IR Spectrometers

3.1K
There are two main infrared (IR) spectrophotometers: dispersive IR spectrometers and Fourier transform infrared (FTIR) spectrometers. In a dispersive IR spectrometer, a beam of infrared radiation produced by a hot wire is divided into two parallel equal-intensity beams using mirrors. One beam passes through the sample, while another is a reference beam. The beams then move through the monochromator, which separates the radiations into a continuous spectrum of different frequencies. The...
3.1K
Raman Spectroscopy Instrumentation: Overview01:26

Raman Spectroscopy Instrumentation: Overview

1.8K
A conventional Raman spectrophotometer includes a laser source, a sample holding system, a wavelength selector, and a detector.
The monochromatic laser source, typically using visible or near-infrared radiation, generates a highly focused beam of light. This light interacts with the molecules of the sample, scattering some of the light. Liquid and gaseous samples are usually tested in ordinary glass capillaries, while solids can be analyzed as powders packed in capillaries or as potassium...
1.8K
Applications of IR Spectroscopy: Overview01:11

Applications of IR Spectroscopy: Overview

2.6K
The non-destructive nature and ability to provide valuable chemical information make IR spectroscopy a versatile technique with broad applications in various scientific and industrial fields. IR spectroscopy is commonly used to identify and characterize organic and inorganic compounds. It provides information about the functional groups present in a molecule and the bonding between atoms. This helps in the structural elucidation of compounds during organic synthesis, pharmaceutical research,...
2.6K
Polymer Classification: Crystallinity01:21

Polymer Classification: Crystallinity

3.1K
Unlike ionic or small covalent molecules, polymers do not form crystalline solids due to the diffusion limitations of their long-chain structures. However, polymers contain microscopic crystalline domains separated by amorphous domains.
Crystalline domains are the regions where polymer chains are aligned in an orderly manner and held together in proximity by intermolecular forces. For example, chains in the crystalline domains of polyethylene and nylon are bound together by van der Waals...
3.1K
IR Spectroscopy: Molecular Vibration Overview01:24

IR Spectroscopy: Molecular Vibration Overview

5.8K
When Infrared (IR) radiation passes through a covalently bonded molecule, the bonds transition from lower to higher vibrational levels. The fundamental vibrational motions that result in infrared absorption can be classified as stretching or bending vibrations.
Stretching vibrations are vibrational motions that occur along the bond line, changing the bond length or distance between two bonded atoms. They are further distinguished as symmetric or asymmetric. In symmetric stretching, the...
5.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Hydroxypropyl cellulose/thermoplastic polyurethane blend films with reversible optical performance triggered by water.

Carbohydrate polymers·2026
Same author

Re-engineering chitin: From poor processability to functional hydrogels via ketone modification and dynamic crosslinking.

Carbohydrate polymers·2026
Same author

Design and synthesis of cellulose ω-carboxythioalkyl alkanoate derivatives for amorphous solid dispersion of hydrophobic compounds.

Carbohydrate polymers·2025
Same author

Well-Defined Amylose Acetate-<i>graft</i>-polylactide Graft Polymers as Compatibilizers for Renewable Polymer Blends.

Biomacromolecules·2025
Same author

Thermodynamics of calcium binding to heparin: Implications of solvation and water structuring for polysaccharide biofunctions.

Proceedings of the National Academy of Sciences of the United States of America·2025
Same author

Efficient, Regioselective Design of Mixed Cellulose Esters and Macroinitiators.

Biomacromolecules·2025

Related Experiment Video

Updated: May 3, 2026

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks
10:31

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Published on: May 8, 2015

13.1K

Mid-infrared spectroscopy as a polymer selection tool for formulating amorphous solid dispersions.

Lindsay A Wegiel1, Lisa J Mauer, Kevin J Edgar

  • 1Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, IN, USA.

The Journal of Pharmacy and Pharmacology
|January 18, 2014
PubMed
Summary
This summary is machine-generated.

Mid-infrared (IR) spectroscopy effectively predicts polymer performance in amorphous solid dispersions. This method aids in selecting polymers that enhance the stability of bioactive compounds against crystallization.

Keywords:
FTIRhydrogen bondingphysical stabilitypolyphenolsolid dispersion

More Related Videos

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

1.4K
Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid
08:54

Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid

Published on: January 25, 2020

5.0K

Related Experiment Videos

Last Updated: May 3, 2026

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks
10:31

Diffuse Reflectance Infrared Spectroscopic Identification of Dispersant/Particle Bonding Mechanisms in Functional Inks

Published on: May 8, 2015

13.1K
Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems
06:54

Author Spotlight: Advances in Nanoscale Infrared Spectroscopy to Explore Multiphase Polymeric Systems

Published on: June 23, 2023

1.4K
Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid
08:54

Vibrational Spectra of a N719-Chromophore/Titania Interface from Empirical-Potential Molecular-Dynamics Simulation, Solvated by a Room Temperature Ionic Liquid

Published on: January 25, 2020

5.0K

Area of Science:

  • Pharmaceutical Sciences
  • Materials Science
  • Spectroscopy

Background:

  • Amorphous solid dispersions (ASDs) are crucial for improving the bioavailability of poorly soluble bioactive compounds.
  • A significant challenge in ASD formulation is the rational selection of polymers to ensure optimal physical stability and prevent crystallization.
  • Existing methodologies often lack the precision to predict polymer efficacy in inhibiting drug crystallization within ASDs.

Purpose of the Study:

  • To evaluate mid-infrared (IR) spectroscopy as a tool for the rational selection of polymers for ASD formulations.
  • To correlate polymer-drug interactions, as measured by mid-IR, with the physical stability of ASDs.
  • To establish a predictive model for polymer performance in inhibiting polyphenol crystallization.

Main Methods:

  • Preparation of amorphous solid dispersions using model polyphenols (quercetin, naringenin) and various polymers (PVP, E100, CMCAB, HPMC, HPMCAS, PAA).
  • Utilized mid-IR spectroscopy to quantify intermolecular interactions between polyphenols and polymers.
  • Employed powder X-ray diffraction (PXRD) to assess the physical stability of ASDs under various environmental conditions (humidity, temperature).

Main Results:

  • Mid-IR analysis provided a rank order of polymer crystallization-inhibiting performance: E100 > PVP > HPMCAS > HPMC ≥ CMCAB > PAA.
  • The physical stability of ASDs correlated directly with the extent of polyphenol-polymer interactions identified by mid-IR spectroscopy.
  • Dispersions with strong intermolecular interactions exhibited superior stability against crystallization, even under stressed conditions.

Conclusions:

  • Mid-IR spectroscopy is a valuable technique for characterizing intermolecular interactions in ASDs.
  • The extent of these interactions directly predicts the crystallization-inhibiting performance of polymers.
  • Mid-IR analysis enables the rational formulation of ASDs with enhanced physical stability.