Related Experiment Video

Updated: May 3, 2026

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment
12:18

A Machine Learning Approach to Design an Efficient Selective Screening of Mild Cognitive Impairment

Published on: January 11, 2020

7.0K

Discerning mild cognitive impairment and Alzheimer Disease from normal aging: morphologic characterization based on

Weiqi Liao1, Xiaojing Long1, Chunxiang Jiang1

  • 1Paul C. Lauterbur Research Center for Biomedical Imaging, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, 1068 Xueyuan Ave., Shenzhen, Guangdong Province 518055, China.

Academic Radiology
|January 18, 2014
PubMed
Abstract

Insights

Alzheimer

Area of Science:

  • Neuroimaging
  • Neurology
  • Gerontology

Background:

  • Distinguishing mild cognitive impairment (MCI) and Alzheimer Disease (AD) from healthy aging is crucial for early intervention.
  • Cerebral structural changes are key indicators of neurodegenerative diseases.

Purpose of the Study:

  • To investigate global and regional cerebral structural alterations in MCI and AD compared to healthy aging.
  • To explore the relationship between morphologic indices and cognitive performance.

Main Methods:

  • Utilized T1-weighted MRI from the Alzheimer Disease Neuroimaging Initiative database (116 subjects).
  • Employed univariate (ANCOVA) and multivariate (MANCOVA) analyses on cortical thickness, surface area, curvature, and white matter volume.
  • Controlled for age and sex in 34 brain regions of interest.

Main Results:

  • Multivariate analysis revealed global structural alterations in MCI and AD groups.
  • Cortical thickness reduction was prominent in entorhinal, temporal, and cingulate cortices, correlating with cognitive performance in AD.
  • White matter atrophy was observed in the temporal lobe, and significant intercorrelations existed among morphologic indices.

Conclusions:

  • MANCOVA identified significant global structural changes in MCI and AD, enhancing diagnostic sensitivity.
  • Intercorrelations among morphologic indices may limit the utility of single parameters.
  • Cortical thickness decrease does not consistently reflect cognitive status in early Alzheimer Disease.
Keywords:
Alzheimer diseaseStructural neuroimagingbrain morphologyhealthy agingmild cognitive impairment

More Related Videos

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment08:43

Application of Granger Causality Analysis of the Directed Functional Connection in Alzheimer's Disease and Mild Cognitive Impairment

Published on: August 7, 2017

7.5K
Basics of Multivariate Analysis in Neuroimaging Data06:35

Basics of Multivariate Analysis in Neuroimaging Data

Published on: July 24, 2010

17.6K

Related Concept Videos

Dementia l: Introduction01:22

Dementia l: Introduction

Dementia is an acquired, progressive syndrome characterized by a decline in multiple cognitive domains severe enough to impair daily functioning and reduce independence. Although memory loss is a central feature, the diagnosis requires additional deficits involving language, executive function, visuospatial skills, judgment, calculation, or abstract reasoning. These cognitive impairments reflect underlying neurodegenerative or vascular processes that gradually disrupt neuronal networks...
35
Alzheimer Disease l: Introduction01:29

Alzheimer Disease l: Introduction

Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...
21
Alzheimer Disease ll: Pathophysiology01:23

Alzheimer Disease ll: Pathophysiology

Alzheimer disease involves structural changes in the brain that begin long before symptoms appear. The most distinctive features are extracellular neuritic plaques and intracellular neurofibrillary tangles.Neuritic plaques form in the cerebral cortex and around blood vessels. These plaques contain a dense core of beta-amyloid (Aβ)—a toxic protein fragment that clumps outside neurons. The core is surrounded by damaged neuronal extensions, as well as reactive astrocytes and...
35
Alzheimer's Disease: Overview01:26

Alzheimer's Disease: Overview

Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ...
1.7K
Dementia01:30

Dementia

Dementia is a collective term for cognitive disorders primarily affecting memory, thinking, and reasoning. It is not a specific disease but a syndrome, with Alzheimer's disease being the most common cause, accounting for approximately 60-80% of cases. Other types include vascular dementia, Lewy body dementia, and frontotemporal dementia. Dementia affects millions worldwide, particularly older adults, though it is not a normal part of aging.
The progression of dementia is generally gradual....
687