Related Experiment Video
Updated: May 3, 2026
06:50
The Use of Mouse Splenocytes to Assess Pathogen-associated Molecular Pattern Influence on Clock Gene Expression
Published on: July 24, 2018
6.8K
[Circadian rhythm and inflammatory bowel disease]
Tomohisa Takagi1, Yutaka Inada1, Yuji Naito1
1Department of Molecular Gastroenterology and Hepatology, Kyoto Prefectural University of Medicine.
Nihon Rinsho. Japanese Journal of Clinical Medicine
|January 21, 2014
Summary
Sleep disturbances are linked to inflammatory bowel disease (IBD) development. Melatonin, a key hormone, regulates inflammation and immune function in the gut, offering potential therapeutic benefits for IBD patients.
Area of Science:
- Gastroenterology and Immunology
- Chronobiology and Sleep Medicine
Context:
- Inflammatory bowel disease (IBD), encompassing ulcerative colitis (UC) and Crohn's disease (CD), is characterized by chronic intestinal inflammation.
- Sleep disturbances are increasingly recognized as a contributing factor in IBD pathogenesis.
- Melatonin, a hormone regulating circadian rhythms, possesses anti-inflammatory and antioxidant properties relevant to intestinal health.
Purpose:
- To review the current understanding of the relationship between sleep disturbances and IBD.
- To explore the multifaceted role of melatonin in modulating intestinal inflammation and immune responses within the context of IBD.
Summary:
- This review consolidates evidence linking sleep disturbances to the development and exacerbation of IBD.
- It highlights melatonin's significant functions in regulating inflammation, immune responses, and antioxidant defense systems in the gastrointestinal tract.
- The interplay between circadian rhythm disruption, sleep quality, and IBD pathophysiology is examined.
Impact:
- Provides a comprehensive overview for researchers and clinicians investigating IBD.
- Suggests potential therapeutic strategies targeting sleep and melatonin pathways for IBD management.
- Enhances understanding of the gut-brain axis and its implications for chronic inflammatory conditions.
Related Concept Videos
01:25Inflammatory Bowel Disease III: Crohn's Disease
35
Crohn’s disease is a chronic, relapsing form of inflammatory bowel disease characterized by segmental, transmural inflammation that can affect any part of the gastrointestinal tract. Its pathogenesis arises from a combination of genetic susceptibility, environmental exposures, epithelial barrier dysfunction, and immune dysregulation. Together, these factors lead to an exaggerated immune response against components of the gut microbiome.Genetic and Environmental InfluencesMultiple genetic...
35
01:20Inflammatory Bowel Disease II: Ulcerative Colitis
34
Ulcerative colitis is a chronic inflammatory disorder of the colon characterized by continuous mucosal inflammation that typically begins in the rectum and extends proximally in a uniform pattern. Its pathogenesis involves a complex interplay of genetic predisposition, immune dysregulation, and environmental influences. These factors converge to impair the colon’s epithelial defenses and promote an exaggerated inflammatory response against luminal contents.Breakdown of the Mucosal...
34
01:30Inflammatory Bowel Disease II: Crohn's Disease
1.6K
Introduction
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
Inflammatory bowel disease, commonly known as IBD, refers to a collection of disorders that lead to persistent inflammation of the gastrointestinal tract. The two types of IBD are ulcerative colitis, which impacts the colon, and Crohn's disease, which can involve any part of the gastrointestinal segment.
Crohn's disease
Crohn's disease is a chronic, systemic inflammatory bowel disease (IBD) that predominantly affects the gastrointestinal tract. It is marked by...
1.6K
01:17Chronic Bowel Disorders: Introduction
900
Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
900
01:20Inflammatory Bowel Disease IV: Clinical Manifestations
33
Inflammatory bowel disease (IBD) encompasses two major chronic disorders—ulcerative colitis and Crohn’s disease—each characterized by relapsing episodes of gastrointestinal inflammation. Although they share certain clinical features, their patterns of involvement and manifestations differ in ways that aid diagnosis and guide management.Ulcerative ColitisUlcerative colitis is limited to the colon and rectum and involves continuous inflammation of the mucosal layer. The...
33
01:26Inflammatory Bowel Disease I: Introduction
42
Inflammatory bowel disease is a group of chronic disorders marked by recurrent inflammation of the gastrointestinal tract due to an abnormal immune response against gut microflora. This leads to tissue damage. The two main forms are Crohn’s disease and ulcerative colitis.Crohn’s DiseaseCrohn’s disease is a relapsing inflammatory disorder that can affect any part of the GI tract, from the mouth to the anus. It involves all layers of the bowel wall (transmural) and shows...
42