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Autologous fibrin tissue adhesive biodegration and systemic effects
D M Harris1, K H Siedentop, K R Ham
1Department of Otolaryngology-Head and Neck Surgery, University of Illinois College of Medicine at Chicago.
The Laryngoscope
|October 1, 1987
Summary
Epsilon amino caproic acid (EACA) prolonged the degradation of Autologous Fibrin Tissue Adhesive (AFTA) in various settings. This fibrinolysis inhibitor showed no observed toxicity, even at high concentrations.
Area of Science:
- Biomaterials Science
- Wound Healing
- Pharmacology
Background:
- Autologous Fibrin Tissue Adhesive (AFTA) is a promising biomaterial for tissue repair.
- Fibrinolysis, the breakdown of fibrin clots, can limit the efficacy of AFTA.
- Epsilon amino caproic acid (EACA) is a known inhibitor of fibrinolysis.
Purpose of the Study:
- To investigate the effect of EACA on the degradation rate of AFTA.
- To evaluate the safety and efficacy of EACA in prolonging AFTA clot duration in various applications.
Main Methods:
- Experiments were conducted in vitro, subcutaneously, and in the middle ear.
- AFTA clot degradation was measured in the presence of varying concentrations of EACA in Component II.
- Toxic reactions and systemic pathology were assessed.
Main Results:
- The duration of AFTA clots was significantly prolonged by EACA in a concentration-dependent manner.
- No toxic reactions were observed in the middle or inner ear.
- No systemic pathology, such as thrombosis or emboli, was linked to EACA administration.
Conclusions:
- EACA effectively inhibits AFTA degradation, extending its duration in localized applications.
- EACA demonstrates a favorable safety profile, with no observed local or systemic toxicity.
- EACA represents a potential adjunct to enhance the performance of AFTA in clinical settings.