Related Experiment Video
Updated: Jul 15, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
Progress toward the understanding of the molecular mechanisms of interferon action
1University of California, Department of Biological Sciences, Santa Barbara 93106.
Abstract:
Results of cellular and molecular analyses of type I (IFN-alpha and IFN-beta) and type II (IFN-gamma) human interferons demonstrate that these proteins differentially regulate the expression of certain cellular genes and induce mechanistically distinct antiviral states in human cells. Although none of the human genes whose expression is regulated by IFN have yet been localized to human chromosome 21, the localization of the receptor for the type I IFNs to chromosome 21 may have important consequences with regard to the functions of the interferon system in Down Syndrome individuals.
More Related Videos
Related Concept Videos
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
RNA Interference
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
Antimicrobial Proteins
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Immune Response Against Viral Pathogens
NK Cells
NK cells are a crucial part of our innate immune system, acting as the first line of defense against viral infections. These cells can recognize and kill infected cells without prior exposure to the virus, effectively slowing down the spread of infection. Additionally, NK cells produce proinflammatory...
Inhibitors of Viral Protein Synthesis
Inhibitors Of Virion Release

