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Published on: October 16, 2021
Incidental moderate mitral regurgitation in patients undergoing coronary artery bypass grafting: update on guidelines
Harish Ramakrishna1, Kamrouz Ghadimi2, John G T Augoustides2
1Mayo Clinic, Scottsdale, AZ.
Insights
Moderate mitral regurgitation (MR) in patients undergoing coronary artery bypass grafting (CABG) may worsen outcomes. New trials and interventions are emerging, suggesting less tolerance for MR in the future.
Area of Science:
- Cardiology
- Cardiac Surgery
- Echocardiography
Background:
- Incidental moderate mitral regurgitation (MR) is common in patients undergoing coronary artery bypass grafting (CABG).
- This condition may adversely affect clinical outcomes.
- Echocardiographic evaluation of MR is crucial for management decisions.
Purpose of the Study:
- To review the current understanding and management of incidental moderate MR in patients undergoing CABG.
- To discuss the implications of ongoing clinical trials and emerging interventions.
Main Methods:
- Review of current guidelines and clinical practice.
- Discussion of ongoing randomized trials comparing CABG with and without mitral intervention.
- Overview of advancements in cardiac resynchronization therapy, transcatheter mitral valve intervention, and minimally invasive surgery.
Main Results:
- Clinical equipoise exists regarding moderate MR in the context of planned CABG.
- Two major randomized trials are underway to assess the benefits of combined surgical correction of moderate MR and CABG.
- Advancements in cardiac interventions offer new management alternatives.
Conclusions:
- Surgical mitral intervention is a reasonable option for moderate MR during CABG.
- Emerging therapies promise improved safety profiles and management options.
- Future management will likely involve less tolerance for incidental moderate MR due to known outcome effects and evolving interventions.
Abstract:
Incidental moderate mitral regurgitation (MR) in patients presenting for coronary artery bypass grafting (CABG) is not only common but also probably adversely affects clinical outcome. The echocardiographic evaluation of incidental MR must be comprehensive and integrated, as it remains a cornerstone in management decisions. Current guidelines support surgical mitral intervention in this setting as a reasonable option, reflecting clinical equipoise towards moderate MR in the setting of planned CABG. There are currently 2 major randomized trials in progress that will test whether surgical correction of moderate MR combined with CABG improves major clinical outcomes as compared to CABG alone. These landmark trials will be completed in the near future. In the interim, significant progress in the fields of cardiac resynchronization therapy, transcatheter mitral valve intervention, and minimally invasive mitral valve surgery promise to affect the management alternatives for moderate MR in patients undergoing CABG regardless of operative risk. It is likely that in the coming decade there will be less tolerance for incidental moderate MR given its already known outcome effects and the multimodal interventions that continue to mature with better safety profiles.
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