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Perforating disorders of the skin
Kalpana Arora1, Kalpana A Hajirnis, Smita Sawant
1Department of pathology, K. J. Somaiya Medical College and Research Centre, Mumbai, Maharashtra, India.
Indian Journal of Pathology & Microbiology
|January 21, 2014
Summary
Perforating skin disorders, characterized by material elimination through the epidermis, include Kyrle's disease and reactive perforating collagenosis. Early recognition of ulcers with keratotic plugs is crucial for diagnosis.
Area of Science:
- Dermatology
- Histopathology
Background:
- Perforating disorders of the skin are characterized by transepidermal elimination of dermal material.
- These conditions are classified based on epidermal disruption and eliminated material type.
- Includes Kyrle's disease, perforating folliculitis, reactive perforating collagenosis, and elastosis perforans serpiginosa.
Observation:
- A review of five skin biopsies over two years was conducted.
- Histopathological evaluation included Hematoxylin and eosin, elastic van Gieson, and Masson trichrome stains.
- Cases included Kyrle's disease (2), reactive perforating collagenosis (2), and perforating folliculitis (1).
Findings:
- Two patients had a family history of perforating dermatosis.
- Three patients presented with associated systemic diseases.
- Clinical and histopathological features of these rare disorders were delineated.
Implications:
- Perforating skin disorders should be considered in cases of ulcers with keratotic plugs.
- Understanding these features aids in accurate diagnosis and management.
- Highlights the importance of histopathological examination in diagnosing skin conditions.
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