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The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
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Related Experiment Video

Updated: May 3, 2026

DNBS/TNBS Colitis Models: Providing Insights Into Inflammatory Bowel Disease and Effects of Dietary Fat
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Hyperamylasaemia and ischaemic colitis.

F Kum1, A Gulati2, A Hussain3

  • 1Department of General Surgery, Princess Royal University Hospital, Farnborough Common BR6 8ND, United Kingdom.

International Journal of Surgery Case Reports
|January 21, 2014
PubMed
Summary
This summary is machine-generated.

Ischaemic colitis, a serious condition causing abdominal pain and rectal bleeding, can present with elevated amylase levels. Prompt surgical intervention may be necessary for severe cases to prevent mortality.

Keywords:
Acute abdomenCardiovascular riskHartmann's procedureHyperamylaesemiaIschaemic colitis

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Area of Science:

  • Gastroenterology
  • Abdominal Surgery
  • Diagnostic Imaging

Background:

  • Ischaemic colitis is a critical diagnosis in high-cardiovascular-risk patients.
  • Severe cases often manifest as acute abdomen with rectal bleeding and hyperamylasemia.

Purpose of the Study:

  • To highlight the diagnostic considerations for ischaemic colitis.
  • To emphasize the role of imaging and clinical presentation in diagnosis.
  • To discuss management strategies and outcomes.

Main Methods:

  • Case report of a 66-year-old male with abdominal pain and rectal bleeding.
  • Diagnosis confirmed via computed tomography (CT) scan and colonoscopy.
  • Treatment involved conservative management followed by laparotomy and Hartmann's procedure.

Main Results:

  • CT revealed colonic thickening and pneumatosis; colonoscopy showed mucosal sloughing and ulceration.
  • Histology confirmed extensive partial and full-thickness ischaemia with stricture.
  • Initial conservative management was insufficient, necessitating surgical intervention.

Conclusions:

  • Hyperamylasemia can be associated with bowel ischaemia, though it is not a specific marker.
  • Distinguishing ischaemic colitis from ulcerative colitis is crucial.
  • Intestinal ischaemia requires prompt surgical intervention to reduce mortality.